School of Social Sciences Social Anthropology, The University of Manchester, Oxford Road Manchester 9PL M13, UK.
Hist Philos Life Sci. 2011;33(2):147-63.
Eric Davidson's work from 1969-2006 illustrates a period in the study of gene regulation that marked a transition from the gene to the genome and from theory-driven to data-intensive science. To make sense of this transition, I address Davidson's work during a first, predominantly theoretical, episode and contrast it with a later chapter in his research devoted to sequencing the California purple sea urchin genome and, more recently, to the computerized analysis of sea urchin development. By comparing these two approaches I offer some thoughts on how work configuration and material organization in the study of metazoan gene regulation have changed over the past forty years.
埃里克·戴维森（Eric Davidson）1969 年至 2006 年的工作展示了基因调控研究中的一个时期，标志着从基因到基因组的转变，以及从理论驱动到数据密集型科学的转变。为了理解这一转变，我在第一个主要是理论性的阶段探讨了戴维森的工作，并将其与他后来研究加利福尼亚紫海胆基因组测序的一个章节进行对比，最近又对海胆发育的计算机分析进行了对比。通过比较这两种方法，我对过去四十年间后生动物基因调控研究中工作配置和物质组织的变化进行了一些思考。
