琥珀酸及相关酸联苯烷基单酯对磷酸二酯酶的抑制作用。
Phosphodiesterase inhibition by succinic and related acid biphenylalkyl monoesters.
作者信息
Rogers M E, Boots S G, Boots M R
出版信息
J Pharm Sci. 1979 Jul;68(7):903-5. doi: 10.1002/jps.2600680732.
PMID:222890
Abstract
Biphenylalkyl monoesters of succinic and related acids represent a potent new class of cyclic AMP phosphodiesterase inhibitors. The biphenyl group is necessary for potent inhibition. The spatial relationship of the carboxyl and ester groups and alkyl chain length are important to inhibitory potency.
摘要
琥珀酸及相关酸的联苯烷基单酯是一类新型强效环磷酸腺苷磷酸二酯酶抑制剂。联苯基团对于强效抑制作用是必需的。羧基、酯基的空间关系以及烷基链长度对抑制效力很重要。
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