Guan J, You C, Liu Y, Liu Y, Zhang R, Wang Z
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
J Int Med Res. 2011;39(6):2281-7. doi: 10.1177/147323001103900625.
This retrospective study investigated the circadian and infradian characteristics of blood pressure and heart rate in 26 patients with traumatic head injury in a persistent vegetative state (PVS). Systolic and diastolic blood pressures and heart rate were measured every hour for the first 240 h (10 days) following hospital admission. These data were analysed for the presence of circadian and infradian rhythms using the least-squares fit of the cosine function with the single cosinor method. Infradian rhythms were defined as biological rhythms with a period of approximately 7 days (circaseptan rhythms). All the patients studied had circadian and circaseptan rhythms of systolic and diastolic blood pressures and heart rate. The amplitudes of all the circaseptan rhythms were significantly greater than those of the corresponding circadian rhythms. It was concluded that there was an altered association between circadian and infradian blood pressure and heart rate rhythms in patients in a PVS. Circadian and infradian rhythms were present, but the infradian rhythm had a greater amplitude than the circadian rhythm.
这项回顾性研究调查了26例持续性植物状态（PVS）创伤性脑损伤患者的血压和心率的昼夜节律及近昼夜节律特征。入院后的前240小时（10天），每小时测量收缩压、舒张压和心率。使用单余弦法通过余弦函数的最小二乘法拟合分析这些数据，以确定昼夜节律和近昼夜节律的存在。近昼夜节律被定义为周期约为7天的生物节律（近周节律）。所有研究患者的收缩压、舒张压和心率均有昼夜节律和近周节律。所有近周节律的幅度均显著大于相应的昼夜节律。得出的结论是，PVS患者的昼夜和近昼夜血压及心率节律之间的关联发生了改变。昼夜节律和近昼夜节律均存在，但近昼夜节律的幅度大于昼夜节律。
