Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, 22nd Main, 24th Cross, BSK-2nd stage, Bangalore-560070, India.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Apr 27;37(1):203-9. doi: 10.1016/j.pnpbp.2012.01.004. Epub 2012 Jan 25.
The effect of prenatal exposure to antitubercular drugs in therapeutic and double therapeutic doses on postnatal developments was studied in albino rats of Wistar strain. Seven groups with six female rats each were taken for the study and were allowed to mate with male in the ratio of (2:1). The drugs isoniazid 27 and 54mg/kg b.w. p.o., ethambutol 144 and 288mg/kg b.w. p.o., rifampin 54 and 108mg/kg b.w. p.o. were administered to each group from the day of pregnancy till parturition. Control group was administered with distilled water (1ml/kg). Litters of the respective groups were studied for litter size; body weight; physical development i.e. eye opening, pinna detachment, incisor eruption; behavioral development i.e. righting reflex, negative geotaxis, ascending wire mesh; motor development i.e. rotarod and cognitive function i.e. elevated plus maze, Hebb-William maze and step-down (passive avoidance). The results obtained indicate that the prenatal exposure to therapeutic dose of rifampin and double therapeutic dose of rifampin, isoniazid and ethambutol affect the postnatal growth, development and cognitive ability. Hence, the study suggests that potential benefit risk ratios to be considered for their use in pregnancy.
研究了治疗剂量和双治疗剂量的抗结核药物在产前暴露对 Wistar 系白化大鼠产后发育的影响。研究采用了 7 组，每组 6 只雌性大鼠，并按照（2:1）的比例与雄性大鼠交配。药物异烟肼 27 和 54mg/kg b.w. p.o.、乙胺丁醇 144 和 288mg/kg b.w. p.o.、利福平 54 和 108mg/kg b.w. p.o.从妊娠第 1 天到分娩期间分别给予每组大鼠。对照组给予蒸馏水（1ml/kg）。研究了各组的产仔数、体重、身体发育（即睁眼、耳壳分离、门齿萌出）、行为发育（即翻正反射、负趋地性、爬网格）、运动发育（即转棒）和认知功能（即高架十字迷宫、Hebb-William 迷宫和跳下（被动回避））。结果表明，产前暴露于治疗剂量的利福平以及双治疗剂量的利福平、异烟肼和乙胺丁醇会影响产后生长、发育和认知能力。因此，该研究表明，在怀孕期间使用这些药物时需要考虑潜在的益处风险比。
