抗中性粒细胞胞浆抗体在川崎病诊断中的价值

[Value of anti-neutrophil cytoplasmic antibody in diagnosis of Kawasaki disease].

作者信息

Jiang Zhi-Gui, Liu Ling, Yang Cui-Yan, Wu Jie

机构信息

Department of Pediatrics, Shunde Longjiang Hospital of Foshan, Foshan, Guangdong 528318, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2012 Jan;14(1):45-7.

PMID:22289752

Abstract

OBJECTIVE

To study the value of anti-neutrophil cytoplasmic antibody (ANCA) in diagnosis of Kawasaki disease (KD).

METHODS

Serum ANCA was detected in 30 children with typical Kawasaki disease (TKD) and in 16 with incomplete Kawasaki disease (IKD) in the acute and the recovery phases respectively. Twenty-five healthy children were randomly selected as a control group. An ultrasonic cardiography (UCG) was performed on children with KD in the acute phase.

RESULTS

The mean positive rate of serum ANCA in the acute phase in KD children was 65%, with 69% in IKD children and 63% in TKD children, which were obviously higher than that in the control group (P<0.01). The positive rate of serum ANCA in the recovery phase in KD children was significantly lower than that in the acute phase (33% vs 65%, P<0.05). The positive rate of serum ANCA in the acute phase in children with KD was significantly higher than that detected by UCG (P<0.01). The incidence rate of coronary artery lesions in children with positive ANCA was obviously higher than that in children with negative ANCA (43% vs 13%; P<0.05).

CONCLUSIONS

Serum ANCA may be used as a reference index for early diagnosis of KD and secondary coronary artery lesions in children.

摘要

目的

研究抗中性粒细胞胞浆抗体（ANCA）在川崎病（KD）诊断中的价值。

方法

分别检测30例典型川崎病（TKD）患儿和16例不完全川崎病（IKD）患儿急性期及恢复期血清ANCA水平。随机选取25例健康儿童作为对照组。对急性期KD患儿进行超声心动图（UCG）检查。

结果

KD患儿急性期血清ANCA平均阳性率为65%，其中IKD患儿为69%，TKD患儿为63%，均明显高于对照组（P<0.01）。KD患儿恢复期血清ANCA阳性率明显低于急性期（33%对65%，P<0.05）。KD患儿急性期血清ANCA阳性率明显高于UCG检查阳性率（P<0.01）。ANCA阳性患儿冠状动脉病变发生率明显高于ANCA阴性患儿（43%对13%；P<0.05）。