Ozen Ahmet Oğuzhan, Ercan Sarıçoban Hülya, Mutlu Nilgün, Cengizlier Mehmet Reha
Department of Pediatric Allergy, Yeditepe University, İstanbul, Turkey.
Agri. 2011 Oct;23(4):174-8. doi: 10.5505/agri.2011.41636.
Migraine is a very common headache disorder. Due to the co-occurrence of migraine and allergic disorders, allergic mechanisms have been thought to play a role in migraine pathophysiology. This study aimed to investigate the association between cow's milk allergy and egg-white allergy and migraine-type headache of childhood.
We included 39 children with migraine-type headache and 167 children with no headache who had been evaluated previously in a school screening study program. Egg-white and cow's milk-specific IgE levels were measured for all involved subjects.
Specific IgE levels were positive for cow's milk in 4 children and for egg-white in 2 children, respectively. No meaningful relationship was detected between food allergies and migraine. However, specific IgE levels for egg-white were significantly higher in migraineurs (p=0.008).
Childhood migraine does not appear to be associated with cow's milk or egg-white allergy. However, the elevation of egg-white-specific IgE levels in migraine-type headache may signify the possible presence of shared pathogenetic pathways in the development of migraine and food allergies.
偏头痛是一种非常常见的头痛疾病。由于偏头痛与过敏性疾病同时出现，过敏机制被认为在偏头痛病理生理学中起作用。本研究旨在调查牛奶过敏和蛋清过敏与儿童偏头痛型头痛之间的关联。
我们纳入了39名偏头痛型头痛儿童和167名无头痛儿童，这些儿童曾在一项学校筛查研究项目中接受过评估。对所有参与研究的受试者测量了蛋清和牛奶特异性IgE水平。
牛奶特异性IgE水平在4名儿童中呈阳性，蛋清特异性IgE水平在2名儿童中呈阳性。未发现食物过敏与偏头痛之间存在有意义的关系。然而，偏头痛患者的蛋清特异性IgE水平显著更高（p=0.008）。
儿童偏头痛似乎与牛奶或蛋清过敏无关。然而，偏头痛型头痛中蛋清特异性IgE水平的升高可能意味着偏头痛和食物过敏在发病机制上可能存在共同途径。
