Bilousov Oleksii O, Kozeretska Iryna A, Katanaev Vladimir L
Genesis. 2012 Jul;50(7):525-33. doi: 10.1002/dvg.22016. Epub 2012 Mar 9.
Miniature is an extracellular zona pellucida domain-containing protein, required for flattening of pupal wing epithelia in Drosophila. Here, we show that Miniature also plays an important role in the post-eclosion wing maturation processes triggered by the neurohormone bursicon. Wing expansion and epithelial apoptosis are drastically delayed in miniature loss-of-function mutants, and sped up upon overexpression of the protein in wings. Miniature acts upstream from the heterotrimeric Gs protein transducing the bursicon signal in wing epithelia. We propose that Miniature interacts with bursicon and regulates its diffusion through or stability within the wing tissue.
微小蛋白是一种含细胞外透明带结构域的蛋白质，在果蝇蛹翅上皮细胞扁平化过程中是必需的。在此，我们表明微小蛋白在神经激素羽化激素引发的羽化后翅膀成熟过程中也发挥着重要作用。在微小蛋白功能丧失突变体中，翅膀扩张和上皮细胞凋亡显著延迟，而在翅膀中过表达该蛋白时则会加速。微小蛋白在异源三聚体Gs蛋白的上游起作用，该蛋白在翅上皮细胞中传导羽化激素信号。我们提出，微小蛋白与羽化激素相互作用，并调节其在翅膀组织中的扩散或稳定性。
