长期苯二氮䓬类药物使用者的记忆功能、警觉性和情绪：正常日剂量影响的初步研究。

Memory functions, alertness and mood of long-term benzodiazepine users: a preliminary investigation of the effects of a normal daily dose.

机构信息

Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.

出版信息

J Psychopharmacol. 1992 Jan;6(1):69-75. doi: 10.1177/026988119200600113.

DOI:10.1177/026988119200600113

Abstract

The effects of a normal daytime dose of a benzodiazepine (BZ) on memory functions and mood were assessed in 20 out-patients who had taken BZs regularly for an average of 10 years. The results implied that these chronic users may have developed tolerance differentially to the sedative, anxiolytic and amnesic effects of one dose of BZ. A daytime dose did not produce subjective sedation. Lack of change in psychomotor performance and certain memory measures may either show tolerance or imply that the drug counteracts a possible practice effect. Anxiety levels decreased markedly after a daily dose, but this does not necessarily imply a purely pharmacological effect. Memory impairments were apparent in terms of increased susceptibility to proactive interference. This impairment was significantly correlated with the dosage of BZ taken.

摘要

在 20 名长期使用苯二氮䓬类药物（BZ）的门诊患者中，评估了正常白天剂量的 BZ 对记忆功能和情绪的影响。结果表明，这些慢性使用者可能对 BZ 镇静、抗焦虑和遗忘作用的剂量产生了不同程度的耐受。白天剂量不会产生主观镇静作用。运动和某些记忆测试的变化不大可能表明耐受，也可能意味着药物对抗了可能的练习效应。每日剂量后焦虑水平明显下降，但这并不一定意味着纯粹的药理作用。记忆障碍表现为对前摄干扰的敏感性增加。这种损害与 BZ 的剂量显著相关。