D-19466，一种具有抗肿瘤活性的新型环丁烷铂配合物。
D-19466, a new cyclobutane-platinum complex with antitumor activity.
作者信息
Voegeli R, Schumacher W, Engel J, Respondek J, Hilgard P
机构信息
ASTA Pharma AG, Frankfurt, Federal Republic of Germany.
出版信息
J Cancer Res Clin Oncol. 1990;116(5):439-42. doi: 10.1007/BF01612990.
Abstract
D-19466, a new platinum complex, was characterized. It showed no nephrotoxic side-effects as determined by the measurement of blood urea. It was cytotoxic in vitro for tumor cells in concentrations comparable to or lower than cytotoxic concentrations of cisplatin. It had excellent anticancer activity in vivo against a number of murine experimental tumors, including a cisplatin-resistant P388 line. Clinical evaluation of this compound has therefore been initiated.
摘要
新型铂配合物D - 19466得到了表征。通过测量血尿素氮确定其无肾毒性副作用。在体外，它对肿瘤细胞具有细胞毒性，其浓度与顺铂的细胞毒性浓度相当或更低。在体内，它对多种小鼠实验性肿瘤具有出色的抗癌活性，包括对顺铂耐药的P388细胞系。因此，已开始对该化合物进行临床评估。
相似文献
1
D-19466, a new cyclobutane-platinum complex with antitumor activity.D-19466，一种具有抗肿瘤活性的新型环丁烷铂配合物。
J Cancer Res Clin Oncol. 1990;116(5):439-42. doi: 10.1007/BF01612990.
2
Different response of murine and human mammary tumour models to a series of diastereoisomeric [1,2-bis(difluorophenyl) ethylenediamine]dichloroplatinum(II) complexes.小鼠和人类乳腺肿瘤模型对一系列非对映异构的[1,2-双（二氟苯基）乙二胺]二氯铂（II）配合物的不同反应。
J Cancer Res Clin Oncol. 1991;117(5):435-43. doi: 10.1007/BF01612764.
3
Synthesis and antitumor activity of a new cis-diammineplatinum (II) complex containing procaine hydrochloride.一种含盐酸普鲁卡因的新型顺二氨合铂（II）配合物的合成及抗肿瘤活性
Anticancer Res. 1992 Nov-Dec;12(6B):2285-92.
4
Hyperthermia enhances the cytotoxicity and platinum-DNA adduct formation of lobaplatin and oxaliplatin in cultured SW 1573 cells.热疗增强了洛铂和奥沙利铂在培养的SW 1573细胞中的细胞毒性及铂-DNA加合物的形成。
J Cancer Res Clin Oncol. 1997;123(1):6-12. doi: 10.1007/BF01212608.
5
Different infusion durations for preventing platinum-induced hearing loss in children with cancer.预防癌症患儿铂类药物所致听力损失的不同输注持续时间
Cochrane Database Syst Rev. 2016 Aug 8(8):CD010885. doi: 10.1002/14651858.CD010885.pub3.
6
Different infusion durations for preventing platinum-induced hearing loss in children with cancer.预防癌症患儿铂类药物所致听力损失的不同输注持续时间
Cochrane Database Syst Rev. 2018 Jul 5;7(7):CD010885. doi: 10.1002/14651858.CD010885.pub4.
7
In vivo and in vitro effectivity of some platinum complexes.
Neoplasma. 1984;31(6):641-7.
8
Antitumor activity of cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2- isopropyl-1,3-dioxolane]platinum(II), a new platinum analogue, as an anticancer agent.新型铂类似物顺式丙二酸根[（4R，5R）-4,5-双（氨甲基）-2-异丙基-1,3-二氧戊环]铂（II）作为抗癌剂的抗肿瘤活性。
Cancer Chemother Pharmacol. 1995;35(5):441-5. doi: 10.1007/s002800050260.
9
Chemical stability, biological activity and cellular uptake of a cisplatin analogue having a 1,2-diarylethyleneamine ligand in cultures of human breast cancer cells.在人乳腺癌细胞培养物中，具有1,2 - 二芳基乙胺配体的顺铂类似物的化学稳定性、生物活性及细胞摄取情况
J Cancer Res Clin Oncol. 1995;121(1):31-8. doi: 10.1007/BF01202726.
10
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
引用本文的文献
1
Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer.洛铂诱导的细胞凋亡需要在非小细胞肺癌中通过活性氧生成由p53介导的p38丝裂原活化蛋白激酶激活。
Front Oncol. 2019 Jul 24;9:538. doi: 10.3389/fonc.2019.00538. eCollection 2019.
2
Nanocarriers for delivery of platinum anticancer drugs.纳米载体用于递送铂类抗癌药物。
Adv Drug Deliv Rev. 2013 Nov;65(13-14):1667-85. doi: 10.1016/j.addr.2013.09.014. Epub 2013 Oct 8.
3
Hyperthermia enhances the cytotoxicity and platinum-DNA adduct formation of lobaplatin and oxaliplatin in cultured SW 1573 cells.热疗增强了洛铂和奥沙利铂在培养的SW 1573细胞中的细胞毒性及铂-DNA加合物的形成。
J Cancer Res Clin Oncol. 1997;123(1):6-12. doi: 10.1007/BF01212608.
4
A clinical screening cooperative group phase II evaluation of lobaplatin (ASTA D-19466) in advanced head and neck cancer.洛铂（ASTA D - 19466）用于晚期头颈癌的临床筛查协作组II期评估
Invest New Drugs. 1995;13(3):253-5. doi: 10.1007/BF00873809.
5
Modulation of cis-diamminedichloroplatinum(II) resistance: a review.顺二氯二氨合铂（II）耐药性的调控：综述
Br J Cancer. 1992 Aug;66(2):227-38. doi: 10.1038/bjc.1992.249.
6
Stability of the new anticancer platinum analogue 1,2-diaminomethyl-cyclobutane-platinum(II)-lactate (lobaplatin; D19466) in intravenous solutions.新型抗癌铂类似物1,2 - 二氨基甲基 - 环丁烷 - 铂（II） - 乳酸盐（乐铂；D19466）在静脉注射液中的稳定性。
Pharm Res. 1992 Jun;9(6):808-11. doi: 10.1023/a:1015815908347.
本文引用的文献
1
Iproplatin and carboplatin induced toxicities: overview of phase II clinical trial conducted by the EORTC Early Clinical Trials Cooperative Group (ECTG).
Eur J Cancer Clin Oncol. 1988 Feb;24(2):255-62. doi: 10.1016/0277-5379(88)90262-3.
2
Carboplatin: current status and future prospects.
Cancer Treat Rev. 1988 Jun;15 Suppl B:17-32. doi: 10.1016/0305-7372(88)90031-x.
3
The tetrazolium dye assay for rapid in vitro assessment of cytotoxicity.
Arzneimittelforschung. 1989 Jul;39(7):747-9.
4
Primary bioassay of human myeloma stem cells.人骨髓瘤干细胞的原代生物测定
J Clin Invest. 1977 Oct;60(4):846-54. doi: 10.1172/JCI108839.
Zotero 插件