Université de Bourgogne, Centre de Recherche INSERM U866, INSERM AVENIR TEAM, 7 Bd Jeanne D'Arc, 21000 Dijon, France.
Anticancer Agents Med Chem. 2012 Oct 1;12(8):852-73. doi: 10.2174/187152012802650048.
Cancers are the largest cause of mortality and morbidity in industrialized countries. Several new concepts have emerged in relation to mechanisms that contribute to the regulation of carcinogenesis processes and associated inflammatory effects such as the modulation of innate immune cells and adaptive immune cells that could infiltrate the tumor. In the tumor microenvironment, there is a delicate balance between antitumor immunity and tumor-originated proinflammatory activity, which weaken antitumor immunity. Consequently; modulation of immune cells and inflammatory processes represent attractive targets for therapeutic intervention in malignant diseases with the goal to restore the sensitivity of cancer cells to chemotherapies and to overcome resistance to current cytotoxic therapies. Numerous studies have reported interesting properties of dietary polyphenols in anticancer strategies notably by their pleiotropic properties on cancer cells, immune cells and inflammation. This review is dedicated to the current knowledge of the mechanisms of polyphenols (resveratrol, curcumin, genistein and epigallocatechin) against cancers through a modulation of the immune system and the pro-inflammatory mediator production. We describe the effects of polyphenols on the adaptative and innate immune cells that could infiltrate the tumor. Reduction of chronic inflammation or its downstream consequences may represent a key mechanism in the fight of cancer development and polyphenols could reduce various pro-inflammatory substance productions through targeting signal transduction or through antioxidant effects. Lastly, we analyze key molecular links between inflammation and tumor progression through nuclear factors such as NFκB or microRNAs.
癌症是工业化国家最大的死亡和发病原因。在促进癌症发生过程和相关炎症效应的调节机制方面，出现了几个新概念，如固有免疫细胞和适应性免疫细胞的调节，这些细胞可以浸润肿瘤。在肿瘤微环境中，抗肿瘤免疫和肿瘤来源的促炎活性之间存在着微妙的平衡，这削弱了抗肿瘤免疫。因此，免疫细胞和炎症过程的调节代表了恶性疾病治疗干预的有吸引力的靶点，目的是恢复癌细胞对化疗的敏感性，并克服对当前细胞毒性疗法的耐药性。许多研究报告了膳食多酚在抗癌策略中的有趣特性，特别是其对癌细胞、免疫细胞和炎症的多效性特性。这篇综述专门讨论了多酚（白藜芦醇、姜黄素、染料木黄酮和表没食子儿茶素没食子酸酯）通过调节免疫系统和促炎介质产生来对抗癌症的机制。我们描述了多酚对可能浸润肿瘤的适应性和固有免疫细胞的影响。减少慢性炎症或其下游后果可能是对抗癌症发展的关键机制，多酚可以通过靶向信号转导或通过抗氧化作用来减少各种促炎物质的产生。最后，我们通过核因子（如 NFκB 或 microRNAs）分析炎症和肿瘤进展之间的关键分子联系。
