(S)-ABOC：一种刚性双环β-氨基酸作为构象诱导剂。
(S)-ABOC: a rigid bicyclic β-amino acid as turn inducer.
机构信息
Institut des Biomolécules Max Mousseron UMR 5247 CNRS-UM1-UM2, Faculté de pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier, France.
出版信息
Org Lett. 2012 Feb 17;14(4):960-3. doi: 10.1021/ol203406v. Epub 2012 Jan 31.
PMID:22292802
Abstract
In order to investigate the ability of the (S)-aminobicyclo[2.2.2]octane-2-carboxylic acid 1 (H-(S)-ABOC-OH) to induce reverse turns into peptides, two model tripeptides, in which this bicyclic unit was incorporated into the second position, were synthesized and analyzed by FT-IR, CD, NMR, and X-ray studies.
摘要
为了研究（S）-氨基双环[2.2.2]辛烷-2-羧酸 1（H-（S）-ABOC-OH）诱导肽形成反向转弯的能力，合成了两个模型三肽，其中该二环单元被引入到第二个位置，并通过傅里叶变换红外光谱（FT-IR）、圆二色性（CD）、核磁共振（NMR）和 X 射线研究进行了分析。
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