过氧化物介导的无过渡金属醇与硝基芳烃的直接酰胺化反应。

Peroxide-mediated transition-metal-free direct amidation of alcohols with nitroarenes.

机构信息

Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, China.

出版信息

Org Lett. 2012 Feb 17;14(4):984-7. doi: 10.1021/ol203211k. Epub 2012 Jan 31.

DOI:10.1021/ol203211k

PMID:22292907

Abstract

An unusual direct amidation of alcohols with nitroarenes mediated by peroxides has been discovered. The reaction tolerated a wide range of functionalities, and various aromatic amides were obtained in moderate to good yields in the absence of transition-metal catalyst. The peroxides and solvents had a significant impact on the reaction yield.

摘要

已发现过氧化物介导的醇与硝基芳烃的不寻常直接酰胺化反应。该反应耐受广泛的官能团，并且在没有过渡金属催化剂的情况下以中等至良好的收率获得各种芳酰胺。过氧化物和溶剂对反应收率有重大影响。