Vidhubala E, Ravikannan R, Mani C S, Muthuvel R, Surendren V, John Paul F U
Department of Psycho-oncology, Cancer Institute, Chennai, India.
Indian J Cancer. 2011 Oct-Dec;48(4):500-6. doi: 10.4103/0019-509X.92257.
The Quality of Life (QOL) questionnaire version I consisted of 38 items that were validated using 392 patients. The experiences gained through the interaction with the patients during the administration of the questionnaire provided a lot of inputs for the improvization of the tool.
The current study is aimed at certain modifications of the QOL questionnaire version I and standardization of the same.
The modifications of version I QOL scale included the change of verbatim, splitting, deleting, and adding of new items. Finally, version II included 42 items. It was administered to 183 cancer patients irrespective of their demographic details for further standardization.
The principal component method with varimax rotation was used. Spearman's product moment correlation and Cronbach's alpha coefficient were used for reliability analysis.
The data were subjected to factor analysis to explore the factors. Eleven factors emerged with the eigenvalue ranging from 8.03 to 1.10 and accounted for 66.7% variance. The first factor contributed maximally, 19.5%, and the remaining 10 factors contributed a total of 46.2% variance on QOL. They are general well-being, physical well-being, psychological well-being, familial relationship, sexual and personal ability, cognitive well-being, optimism and belief, economical well-being, information support, patient-physician relationship, and body image. The Cronbach alpha of 0.90 and split-half reliability of 0.80 indicated a high reliability of the tool.
The factor structure showed that QOL is a multidimensional concept having different aspects. The Cancer Institute QOL Questionnaire version II for cancer patients is found to be a valid and reliable tool and feasible to administer at the clinical settings.
生活质量（QOL）问卷第一版包含38个项目，通过对392名患者进行验证。在问卷发放过程中与患者互动所获得的经验为该工具的改进提供了许多依据。
本研究旨在对生活质量问卷第一版进行某些修改并使其标准化。
第一版生活质量量表的修改包括逐字修改、拆分、删除和添加新项目。最终，第二版包含42个项目。将其发放给183名癌症患者，无论其人口统计学细节如何，以进行进一步标准化。
采用主成分分析法并进行方差最大化旋转。使用斯皮尔曼积矩相关系数和克朗巴哈α系数进行信度分析。
对数据进行因子分析以探索相关因素。共出现11个因子，特征值范围为8.03至1.10，解释了66.7%的方差。第一个因子贡献最大，为19.5%，其余10个因子对生活质量的方差贡献总计为46.2%。它们分别是总体幸福感、身体幸福感、心理幸福感、家庭关系、性与个人能力、认知幸福感、乐观与信念、经济幸福感、信息支持、医患关系和身体形象。克朗巴哈α系数为0.90，分半信度为0.80，表明该工具具有较高的信度。
因子结构表明生活质量是一个具有不同方面的多维概念。癌症研究所癌症患者生活质量问卷第二版被发现是一种有效且可靠的工具，在临床环境中易于实施。
