Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
FEBS Lett. 2012 Mar 23;586(6):740-6. doi: 10.1016/j.febslet.2012.01.031. Epub 2012 Jan 27.
The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation in the unc-71/adm-1 gene, which rescued the AVM neuron migration defect in mig-13 mutants. Genetic analyses revealed that UNC-71 at least partly acts downstream of MIG-13 and has an inhibitory effect on the anterior cell migration. The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
跨膜蛋白 MIG-13 是秀丽隐杆线虫神经细胞向前迁移所必需的关键调节因子，但涉及的信号机制仍不清楚。在这里，我们分离出unc-71/adm-1 基因中的一个抑制突变，该突变挽救了 mig-13 突变体中 AVM 神经元迁移缺陷。遗传分析表明 UNC-71 至少部分地作为 MIG-13 的下游发挥作用，并对前体细胞迁移具有抑制作用。unc-71 突变也挽救了 src-1 突变体中 AVM 神经元的前迁移缺陷。这些发现表明 MIG-13 通过与秀丽隐杆线虫中的 UNC-71 和 SRC-1 相互作用来控制前后细胞迁移。
