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In vivo measurement of blood-brain barrier permeability.

作者信息

Boje Kathleen M K

机构信息

University at Buffalo, School of Pharmacy, Buffalo, New York, USA.

出版信息

Curr Protoc Pharmacol. 2002 Aug;Chapter 7:Unit 7.4. doi: 10.1002/0471141755.ph0704s17.

DOI:10.1002/0471141755.ph0704s17
PMID:22294082
Abstract

This unit describes various protocols for the in vivo quantitation of drug permeability across the rodent blood-brain barrier. Methods for the measurement of drug influx and efflux are described, and support protocols are provided for determining intravascular capillary volume and cerebral perfusion flow. An in situ perfusion technique is also provided for assessing whether transport of a test compound occurs by carrier-mediated or saturable transport.

摘要

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