作为药物研发工具的人类膀胱癌小鼠模型
Mouse models of human bladder cancer as a tool for drug discovery.
作者信息
Seager Catherine, Puzio-Kuter Anna M, Cordon-Cardo Carlos, McKiernan James, Abate-Shen Cory
机构信息
Department of Urology, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, New York, New York, USA.
出版信息
Curr Protoc Pharmacol. 2010 Jun;Chapter 14:Unit14.14. doi: 10.1002/0471141755.ph1414s49.
Abstract
Muscle-invasive bladder cancer is a deadly condition in dire need of effective new treatments. This unit contains a description of mouse models suitable for the evaluation of potential new therapies. Included is a genetically engineered mouse model of bladder cancer generated by the delivery of an adenovirus expressing Cre recombinase into the bladder lumen. Also described is an orthotopic mouse model created by the instillation of human bladder tumor cells into the bladder lumen of immune deficient mice. Protocols are also provided on the use of these models for the preclinical evaluation of new chemical entities, with mTOR inhibitors shown as an example.
摘要
肌肉浸润性膀胱癌是一种急需有效新疗法的致命疾病。本单元包含适用于评估潜在新疗法的小鼠模型描述。其中包括通过将表达Cre重组酶的腺病毒递送至膀胱腔内而产生的膀胱癌基因工程小鼠模型。还描述了通过将人膀胱肿瘤细胞注入免疫缺陷小鼠的膀胱腔内而创建的原位小鼠模型。还提供了使用这些模型对新化学实体进行临床前评估的方案，并以mTOR抑制剂为例。
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