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本文引用的文献

1
Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer.膀胱内给予雷帕霉素抑制进展性膀胱癌小鼠模型中的肿瘤发生。
Cancer Prev Res (Phila). 2009 Dec;2(12):1008-14. doi: 10.1158/1940-6207.CAPR-09-0169. Epub 2009 Dec 1.
2
Inactivation of p53 and Pten promotes invasive bladder cancer.p53和Pten的失活会促进浸润性膀胱癌。
Genes Dev. 2009 Mar 15;23(6):675-80. doi: 10.1101/gad.1772909. Epub 2009 Mar 4.
3
Molecular pathogenesis and diagnostics of bladder cancer.膀胱癌的分子发病机制与诊断
Annu Rev Pathol. 2009;4:251-85. doi: 10.1146/annurev.pathol.4.110807.092230.
4
Molecular alterations associated with bladder cancer initiation and progression.与膀胱癌起始和进展相关的分子改变。
Scand J Urol Nephrol Suppl. 2008 Sep(218):154-65. doi: 10.1080/03008880802291915.
5
Bladder cancer subtypes defined by genomic alterations.由基因组改变定义的膀胱癌亚型。
Scand J Urol Nephrol Suppl. 2008 Sep(218):116-30. doi: 10.1080/03008880802284605.
6
Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model.在临床前小鼠模型中，靶向AKT/mTOR和ERK MAPK信号通路可抑制激素难治性前列腺癌。
J Clin Invest. 2008 Sep;118(9):3051-64. doi: 10.1172/JCI34764.
7
Euthanasia.安乐死。
Curr Protoc Immunol. 2006 Jul;Chapter 1:1.8.1-1.8.4. doi: 10.1002/0471142735.im0108s73.
8
Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer.激活蛋白-1转录因子与前列腺癌的进展和复发相关。
Cancer Res. 2008 Apr 1;68(7):2132-44. doi: 10.1158/0008-5472.CAN-07-6055.
9
Techniques for mammalian cell tissue culture.哺乳动物细胞组织培养技术。
Curr Protoc Mol Biol. 2006 May;Appendix 3:Appendix 3F. doi: 10.1002/0471142727.mba03fs74.
10
A validated mouse model for orthotopic bladder cancer using transurethral tumour inoculation and bioluminescence imaging.一种经尿道肿瘤接种和生物发光成像验证的原位膀胱癌小鼠模型。
BJU Int. 2007 Dec;100(6):1377-84. doi: 10.1111/j.1464-410X.2007.07165.x. Epub 2007 Sep 10.

作为药物研发工具的人类膀胱癌小鼠模型

Mouse models of human bladder cancer as a tool for drug discovery.

作者信息

Seager Catherine, Puzio-Kuter Anna M, Cordon-Cardo Carlos, McKiernan James, Abate-Shen Cory

机构信息

Department of Urology, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, New York, New York, USA.

出版信息

Curr Protoc Pharmacol. 2010 Jun;Chapter 14:Unit14.14. doi: 10.1002/0471141755.ph1414s49.

DOI:10.1002/0471141755.ph1414s49
PMID:22294368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3272628/
Abstract

Muscle-invasive bladder cancer is a deadly condition in dire need of effective new treatments. This unit contains a description of mouse models suitable for the evaluation of potential new therapies. Included is a genetically engineered mouse model of bladder cancer generated by the delivery of an adenovirus expressing Cre recombinase into the bladder lumen. Also described is an orthotopic mouse model created by the instillation of human bladder tumor cells into the bladder lumen of immune deficient mice. Protocols are also provided on the use of these models for the preclinical evaluation of new chemical entities, with mTOR inhibitors shown as an example.

摘要

肌肉浸润性膀胱癌是一种急需有效新疗法的致命疾病。本单元包含适用于评估潜在新疗法的小鼠模型描述。其中包括通过将表达Cre重组酶的腺病毒递送至膀胱腔内而产生的膀胱癌基因工程小鼠模型。还描述了通过将人膀胱肿瘤细胞注入免疫缺陷小鼠的膀胱腔内而创建的原位小鼠模型。还提供了使用这些模型对新化学实体进行临床前评估的方案，并以mTOR抑制剂为例。