在小鼠中建立膀胱癌模型：机遇与挑战。

Kobayashi Takashi, Owczarek Tomasz B, McKiernan James M, Abate-Shen Cory

Department of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

1] Department of Urology, Columbia University Medical Center. [2] Institute of Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA.

Nat Rev Cancer. 2015 Jan;15(1):42-54. doi: 10.1038/nrc3858.

The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding of bladder cancer progression, as well as to affect its diagnosis and treatment. However, relatively few mouse models of bladder cancer have been described, and in particular, few that develop invasive cancer phenotypes. This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer.

在过去20年里，膀胱癌的预后和治疗进展甚微。膀胱癌仍然是一种使人衰弱且往往致命的疾病，也是治疗成本最高的癌症之一。构建信息丰富的小鼠模型有潜力增进我们对膀胱癌进展的理解，并影响其诊断和治疗。然而，已描述的膀胱癌小鼠模型相对较少，尤其是很少有能产生浸润性癌表型的模型。本综述着重探讨改善膀胱癌小鼠模型现状的机会。