唾液蛋白和可溶性 CD44 水平作为头颈部鳞状细胞癌早期检测的潜在筛查工具。
Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma.
机构信息
Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida, USA.
出版信息
Head Neck. 2012 May;34(5):687-95. doi: 10.1002/hed.21810. Epub 2011 Jul 11.
BACKGROUND
Head and neck squamous cell carcinoma (HNSCC) is a devastating disease usually diagnosed at a late stage when cure rates are 40%. We examined a simple and inexpensive molecular tool that may aid HNSCC detection.
METHODS
Building on prior findings that total protein levels are elevated in 102 HNSCC cases versus 84 control subjects, we further analyzed these levels with respect to important risk and demographic variables and compared the results to soluble CD44 (solCD44). Using multivariate adaptive regression splines (MARSs)-logit modeling and logistic regression, we determined whether total protein, solCD44, or the combination best identifies HNSCC.
RESULTS
Combined higher levels of solCD44 and protein were significantly associated with HNSCC (odds ratio [OR] = 24.90; 95% confidence interval [CI], 9.04-68.57; area under the curve [AUC] = 0.786). A model including protein plus solCD44 resulted in a better area (AUC 0.796) than either marker alone.
CONCLUSION
Oral rinse levels of solCD44 and protein seem to hold promise for detection of HNSCC.
背景
头颈部鳞状细胞癌（HNSCC）是一种破坏性疾病，通常在晚期诊断，此时治愈率为 40%。我们研究了一种简单且廉价的分子工具，它可能有助于 HNSCC 的检测。
方法
基于先前的发现，即 102 例 HNSCC 病例与 84 例对照相比，总蛋白水平升高，我们进一步分析了这些水平与重要的风险和人口统计学变量的关系，并将结果与可溶性 CD44（solCD44）进行了比较。使用多变量自适应回归样条（MARS）-logit 模型和逻辑回归，我们确定了总蛋白、solCD44 或两者的组合是否可以最佳识别 HNSCC。
结果
高水平的 solCD44 和蛋白质联合与 HNSCC 显著相关（比值比 [OR] = 24.90；95%置信区间 [CI]，9.04-68.57；曲线下面积 [AUC] = 0.786）。包含蛋白质和 solCD44 的模型比单独使用任何一种标志物的 AUC 更好（AUC 0.796）。
结论
口腔冲洗液中 solCD44 和蛋白质的水平似乎对头颈部鳞状细胞癌的检测有一定的前景。
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