体外活性的铁载体单肟 BAL30072 对美罗培南不敏感鲍曼不动杆菌。
In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii.
机构信息
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
出版信息
J Antimicrob Chemother. 2012 May;67(5):1167-9. doi: 10.1093/jac/dks009. Epub 2012 Feb 1.
OBJECTIVES
The activity of BAL30072 was compared with that of anti-Acinetobacter reference drugs against meropenem-non-susceptible Acinetobacter baumannii isolates associated with up-regulation of the intrinsic OXA-51-like enzyme or an acquired OXA.
METHODS
Antimicrobial susceptibility testing was investigated by broth microdilution of 310 non-duplicate, meropenem-non-susceptible A. baumannii isolates to BAL30072, amikacin ampicillin/sulbactam, aztreonam, cefepime, colistin, imipenem, levofloxacin, meropenem, rifampicin, tigecycline and tobramycin.
RESULTS
BAL30072 showed greater activity than the β-lactam comparators, levofloxacin, amikacin, tobramycin and rifampicin. The activity of BAL30072 was comparable to that of tigecycline, with an MIC(50) of 2 mg/L. Elevated BAL30072 MICs were found, but there was no correlation with elevated MICs of the other antimicrobials.
CONCLUSIONS
BAL30072 is a promising new agent with good activity against carbapenem-non-susceptible A. baumannii.
目的
比较 BAL30072 与抗不动杆菌参考药物对上调固有 OXA-51 样酶或获得性 OXA 的耐美罗培南鲍曼不动杆菌分离株的活性。
方法
通过肉汤微量稀释法对 310 个非重复的耐美罗培南鲍曼不动杆菌分离株进行药敏试验，检测 BAL30072、阿米卡星-氨苄西林/舒巴坦、氨曲南、头孢吡肟、黏菌素、亚胺培南、左氧氟沙星、美罗培南、利福平、替加环素和妥布霉素对 BAL30072 的敏感性。
结果
BAL30072 对β-内酰胺类药物比较剂、左氧氟沙星、阿米卡星、妥布霉素和利福平的活性更强。BAL30072 的活性与替加环素相当，MIC50 为 2mg/L。发现 BAL30072 的 MIC 升高，但与其他抗菌药物的 MIC 升高无相关性。
结论
BAL30072 是一种有前景的新型药物，对耐碳青霉烯鲍曼不动杆菌具有良好的活性。
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