基于人群的 DNA 图像细胞术作为食管癌筛查方法的研究。
Population-based study of DNA image cytometry as screening method for esophageal cancer.
机构信息
Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
出版信息
World J Gastroenterol. 2012 Jan 28;18(4):375-82. doi: 10.3748/wjg.v18.i4.375.
AIM
To explore the DNA image cytometry (DNA-ICM) technique as a primary screening method for esophageal squamous precancerous lesions.
METHODS
This study was designed as a population-based screening study. A total of 582 local residents aged 40 years-69 years were recruited from Linzhou in Henan and Feicheng in Shandong. However, only 452 subjects had results of liquid-based cytology, DNA-ICM and pathology. The sensitivity and specificity of DNA-ICM were calculated and compared with liquid-based cytology in moderate dysplasia or worse.
RESULTS
Sensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%, 86.36%, 79.55% and 77.27%, respectively, which were better than that of liquid-based cytology (75%). Specificities of DNA-ICM were 70.83%, 84.07%, 92.65% and 96.81%, but the specificity of liquid-based cytology was 91.91%. The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%, respectively.
CONCLUSION
It is possible to use DNA-ICM technique as a primary screening method for esophageal squamous precancerous lesions.
目的
探讨 DNA 图像细胞计量术（DNA-ICM）作为食管鳞状上皮癌前病变初筛方法的价值。
方法
本研究设计为基于人群的筛查研究。共招募了来自河南林州和山东肥城的 582 名 40 岁至 69 岁的本地居民。然而，只有 452 名受试者有液基细胞学、DNA-ICM 和病理学的结果。计算并比较了 DNA-ICM 与液基细胞学在中度不典型增生或更严重病变时的灵敏度和特异性。
结果
至少有 1 到 4 个非整倍体细胞的 DNA-ICM 的灵敏度分别为 90.91%、86.36%、79.55%和 77.27%，均优于液基细胞学（75%）。DNA-ICM 的特异性分别为 70.83%、84.07%、92.65%和 96.81%，而液基细胞学的特异性为 91.91%。液基细胞学联合 DNA-ICM 的灵敏度和特异性分别为 84.09%和 85.78%。
结论
DNA-ICM 技术有可能作为食管鳞状上皮癌前病变的初筛方法。
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