Oakwood Hospital and Medical Center, Dearborn.
Infect Drug Resist. 2012;5:9-16. doi: 10.2147/IDR.S22587. Epub 2012 Jan 11.
Liposomal amphotericin B is a "true" liposomal formulation of amphotericin B with greatly reduced nephrotoxicity and minimal infusion-related toxicity. This broad spectrum polyene is well tolerated and effective against most invasive fungal infections. In view of the current limitations on diagnostic capability of invasive fungal infections, most clinicians are often compelled to use antifungal drugs in an empiric manner; liposomal amphotericin B continues to play an important role in the empiric management of invasive fungal infections, despite the recent availability of several other drugs in the azole and echinocandin classes.
脂质体两性霉素 B 是两性霉素 B 的一种“真正”脂质体制剂，具有大大降低的肾毒性和最小的输注相关毒性。这种广谱多烯类药物耐受性良好，对大多数侵袭性真菌感染均有效。鉴于目前对侵袭性真菌感染的诊断能力有限，大多数临床医生经常被迫采用经验性方法使用抗真菌药物；尽管最近唑类和棘白菌素类药物有几种其他药物可用，但脂质体两性霉素 B 在侵袭性真菌感染的经验性治疗中仍发挥着重要作用。
