INSA-Lyon, INRA, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur 20 av. Albert Einstein, Villeurbanne F-69621, France.
Toxins (Basel). 2011 Dec;3(12):1502-17. doi: 10.3390/toxins3121502. Epub 2011 Dec 8.
PA1b (Pea Albumin 1, subunit b) is a peptide extract from pea seeds showing significant insecticidal activity against certain insects, such as cereal weevils (genus Sitophilus), the mosquitoes Culex pipiens and Aedes aegyptii, and certain species of aphids. PA1b has great potential for use on an industrial scale and for use in organic farming: it is extracted from a common plant; it is a peptide (and therefore suitable for transgenic applications); it can withstand many steps of extraction and purification without losing its activity; and it is present in a seed regularly consumed by humans and mammals without any known toxicity or allergenicity. The potential of this peptide to limit pest damage has stimulated research concerning its host range, its mechanism of action, its three-dimensional structure, the natural diversity of PA1b and its structure-function relationships.
PA1b（豌豆白蛋白 1，亚基 b）是从豌豆种子中提取的一种肽，对某些昆虫具有显著的杀虫活性，如谷物象鼻虫（Sitophilus 属）、库蚊（Culex pipiens）和埃及伊蚊（Aedes aegyptii），以及某些蚜虫。PA1b 具有在工业规模上应用和在有机农业中应用的巨大潜力：它从一种常见植物中提取；它是一种肽（因此适合转基因应用）；它可以在不失去其活性的情况下经受许多提取和纯化步骤；而且它存在于一种经常被人类和哺乳动物食用的种子中，没有任何已知的毒性或致敏性。这种肽限制害虫损害的潜力激发了对其宿主范围、作用机制、三维结构、PA1b 的自然多样性及其结构-功能关系的研究。
