Savin R C, Zaias N
Department of Dermatology, Yale University School of Medicine, New Haven, CT.
J Am Acad Dermatol. 1990 Oct;23(4 Pt 2):804-7. doi: 10.1016/0190-9622(90)70293-q.
Terbinafine is an orally and topically active fungicidal drug of the allylamine series. Its oral efficacy at 125 mg taken twice daily was evaluated in a randomized, double-blind, placebo-controlled study in moccasin-type tinea pedis. The study was conducted simultaneously in two centers and consisted of 41 evaluable cases (23 terbinafine, 18 placebo). Mycologic cure and near to complete clearing of signs and symptoms were obtained in 59% of the terbinafine-treated patients after 6 weeks of treatment and in 65% at 2 weeks after treatment. Corresponding efficacy for placebo-treated patients was zero at both evaluations. Side effects in both groups were minimal. We conclude that terbinafine is well tolerated and highly effective in moccasin-type tinea pedis.
特比萘芬是一种口服和外用均有效的烯丙胺类杀真菌药物。在一项针对足癣型足癣的随机、双盲、安慰剂对照研究中，评估了每日两次服用125毫克特比萘芬的口服疗效。该研究在两个中心同时进行，共有41例可评估病例（23例服用特比萘芬，18例服用安慰剂）。治疗6周后，59%服用特比萘芬的患者实现了真菌学治愈且体征和症状几乎完全消除，治疗2周后这一比例为65%。在两次评估中，服用安慰剂患者的相应疗效均为零。两组的副作用都很小。我们得出结论，特比萘芬在足癣型足癣中耐受性良好且疗效显著。
