使用[18F]FDG通过PET对脂肪肉瘤进行分级。
Grading liposarcomas with PET using [18F]FDG.
作者信息
Adler L P, Blair H F, Williams R P, Pathria M N, Makley J T, Joyce M J, al-Kaisi N, Miraldi F
机构信息
Department of Radiology, University Hospitals of Cleveland, OH 44106.
出版信息
J Comput Assist Tomogr. 1990 Nov-Dec;14(6):960-2. doi: 10.1097/00004728-199011000-00017.
Five patients with liposarcomas of the thigh were studied using positron emission tomography (PET) with [18F]2-deoxy-2-fluoroglucose (FDG). There were three low-grade tumors (all National Cancer Institute Grade 1 myxoid liposarcomas) and two high-grade tumors (both pleomorphic liposarcomas, Grades 2 and 3). The low-grade liposarcomas were easily identified with an average dose uptake ratio (DUR) of 1.38 +/- 0.045 (mean +/- SD). The high-grade lesions were more avid for FDG with a mean DUR of 2.45 +/- 0.24. There was a significant difference (p = 0.004) in the DUR for the two groups and the histological grade of malignancy was highly correlated with the DUR for FDG (Rho = 0.89). These findings suggest that FDG-PET may be useful for distinguishing between low-grade and high-grade liposarcomas.
对5例大腿脂肪肉瘤患者使用[18F]2-脱氧-2-氟葡萄糖（FDG）进行正电子发射断层扫描（PET）研究。其中有3例低级别肿瘤（均为美国国立癌症研究所1级黏液样脂肪肉瘤）和2例高级别肿瘤（均为多形性脂肪肉瘤，2级和3级）。低级别脂肪肉瘤很容易识别，平均剂量摄取率（DUR）为1.38±0.045（均值±标准差）。高级别病变对FDG摄取更活跃，平均DUR为2.45±0.24。两组的DUR存在显著差异（p = 0.004），恶性组织学分级与FDG的DUR高度相关（Rho = 0.89）。这些发现表明，FDG-PET可能有助于区分低级别和高级别脂肪肉瘤。
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