Inoue T, Kim E E, Wong F C, Yang D J, Bassa P, Wong W H, Korkmaz M, Tansey W, Hicks K, Podoloff D A
Department of Nuclear Medicine, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
J Nucl Med. 1996 Sep;37(9):1472-6.
Two commonly used tumor-seeking agents for PET are 2-deoxy-2-18F-fluoro-D-glucose (FDG) and L-methyl-11C-methionine (Met). This study compared FDG and Met in detecting residual or recurrent malignant tumors in the same patients.
Thirty-four lesions in 24 patients with clinically suspected recurrent or residual tumors were studied with PET using Met as well as FDG. FDG scans were conducted 1 hr after the completion of PET with Met. The color-coded superimposed images of standardized uptake values (SUVs) and transmission data were produced, and the peak SUVs in the lesions were then evaluated. Lesions above 2.5 SUV were interpreted as positive results for active tumor.
The sensitivity of FDG-PET and Met-PET were 64.5% (20/31 lesions) and 61.3% (19/31 lesions), respectively. The mean SUV of FDG in residual or recurrent malignant tumors (n = 31) was significantly higher than that of Met but there was a significant correlation (r = 0.788, p < 0.01) between FDG and Met SUVs in all lesions (n = 34).
PET using FDG and Met appear equally effective in detecting residual or recurrent malignant tumors although FDG uptakes were slightly higher than Met uptakes. Both showed a limited diagnostic sensitivity for small (< 1.5 cm) tumors.
两种常用于正电子发射断层扫描（PET）的肿瘤寻踪剂是2-脱氧-2-¹⁸F-氟-D-葡萄糖（FDG）和L-甲基-¹¹C-蛋氨酸（Met）。本研究在同一患者中比较了FDG和Met在检测残留或复发性恶性肿瘤方面的效果。
对24例临床怀疑有肿瘤复发或残留的患者的34个病灶进行了PET检查，使用了Met以及FDG。在完成Met的PET检查后1小时进行FDG扫描。生成了标准化摄取值（SUV）和透射数据的彩色编码叠加图像，然后评估病灶中的SUV峰值。SUV大于2.5被解释为活动性肿瘤的阳性结果。
FDG-PET和Met-PET的敏感性分别为64.5%（20/31个病灶）和61.3%（19/31个病灶）。残留或复发性恶性肿瘤（n = 31）中FDG的平均SUV显著高于Met，但在所有病灶（n = 34）中，FDG和Met的SUV之间存在显著相关性（r = 0.788，p < 0.01）。
尽管FDG摄取略高于Met摄取，但使用FDG和Met的PET在检测残留或复发性恶性肿瘤方面似乎同样有效。两者对小（<1.5 cm）肿瘤的诊断敏感性均有限。
