超高龄肝细胞癌患者肝切除术的疗效。
Outcome of hepatectomy in super-elderly patients with hepatocellular carcinoma.
机构信息
Departments of Digestive and Transplant Surgery, Institute of Health Bioscience, Graduate School of Medicine, The University of Tokushima, Kuramoto Department of Surgery, Tokushima Municipal Hospital, Tokushima, Japan.
出版信息
Hepatol Res. 2012 May;42(5):454-8. doi: 10.1111/j.1872-034X.2011.00952.x. Epub 2012 Feb 1.
AIM
The aim of this study was to investigate the characteristics of super-elderly hepatocellular carcinoma (HCC) patients aged 80 years or more who underwent hepatectomy and to clarify whether elderly patients with HCC benefit from hepatectomy.
METHODS
Between March 1992 and December 2008, 278 patients who underwent curative hepatectomy for HCC were investigated. Super-elderly patients were defined as those aged 80 years or more. Clinicopathological data and outcomes after hepatectomy were compared between super-elderly and non-super-elderly groups.
RESULTS
Preoperative parameters, such as biochemical examinations, and liver function tests in the non-super-elderly group were comparable with those of the super-elderly group (n = 11). Exceptionally, albumin level in the super-elderly group was lower than that in the non-super-elderly group (P = 0.03). Surgical data and the prevalence of postoperative complications did not differ significantly between the two groups. No mortality was observed in the super-elderly and non-super-elderly group.
CONCLUSIONS
Hepatectomy for HCC was a feasible option even in super elderly patients aged 80 years or older with accurate selection.
目的
本研究旨在探讨 80 岁及以上行肝切除术的超高龄肝细胞癌（HCC）患者的特点，并阐明 HCC 老年患者是否从肝切除术中获益。
方法
本研究回顾性分析了 1992 年 3 月至 2008 年 12 月期间 278 例行根治性肝切除术的 HCC 患者。超高龄患者定义为年龄 80 岁及以上者。比较超高龄组与非超高龄组患者的肝切除术围手术期临床病理资料和术后结局。
结果
非超高龄组与超高龄组患者的术前参数（如生化检查和肝功能检查）相当（n=11）。但超高龄组患者的白蛋白水平显著低于非超高龄组（P=0.03）。两组患者的手术数据和术后并发症发生率无显著差异。超高龄组和非超高龄组均未观察到死亡病例。
结论
对于 HCC 超高龄患者（80 岁及以上），在准确选择的情况下，肝切除术是一种可行的选择。
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