80岁及以上肝细胞癌患者肝切除术后的结果。

Outcome of hepatectomy in hepatocellular carcinoma patients aged 80 years and older.

作者信息

Tsujita Eiji, Utsunomiya Tohru, Yamashita Yo-ichi, Ohta Mitsuhiko, Tagawa Tetsuzo, Matsuyama Ayumi, Okazaki Jin, Yamamoto Manabu, Tsutsui Shin-ichi, Ishida Teruyoshi

机构信息

Department of Surgery, Hiroshima Red Cross Hospital, Hiroshima, Japan.

出版信息

Hepatogastroenterology. 2012 Jul-Aug;59(117):1553-5. doi: 10.5754/hge09485.

DOI:10.5754/hge09485

PMID:22683972

Abstract

BACKGROUND/AIMS: The aim of this retrospective study was to determine the effect of age on the outcome of hepatic resection in octogenarian patients with hepatocellular carcinoma (HCC).

METHODOLOGY

Data of 408 consecutive primary HCC patients who underwent curative hepatectomy were studied. The surgical results of the younger group (<80 years of age) and the elderly group (≥80 years of age) were compared.

RESULTS

Preoperative parameters, such as comorbid conditions and liver function tests, of the younger group (n=385) were comparable with those of the elderly group (n=23). Surgical data and the prevalence of postoperative complications did not differ significantly between the two groups. The long-term prognosis of the elderly group patients was almost identical to that of the younger group patients. Overall 3-year survival rates for the elderly group and the younger group were 95.7% vs. 84.8%, respectively (p=0.56). Disease-free three-year survival rates for the elderly group and the younger group were 47.2% vs. 47.7%, respectively (p=0.65).

CONCLUSIONS

Hepatectomy is a viable treatment alternative with satisfactory surgical outcome for HCC even in patients aged 80 years or older.

摘要

背景/目的：本回顾性研究旨在确定年龄对80岁及以上肝细胞癌（HCC）患者肝切除术后结局的影响。

方法

研究了408例连续接受根治性肝切除术的原发性HCC患者的数据。比较了较年轻组（<80岁）和老年组（≥80岁）的手术结果。

结果

较年轻组（n = 385）的术前参数，如合并症和肝功能检查，与老年组（n = 23）相当。两组之间的手术数据和术后并发症发生率无显著差异。老年组患者的长期预后与较年轻组患者几乎相同。老年组和较年轻组的总体3年生存率分别为95.7%和84.8%（p = 0.56）。老年组和较年轻组的无病三年生存率分别为47.2%和47.7%（p = 0.65）。