自噬体相关蛋白 1/p62：疾病相关。
Sequestosome 1/p62: across diseases.
机构信息
Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
出版信息
Biomarkers. 2012 Mar;17(2):99-103. doi: 10.3109/1354750X.2011.653986. Epub 2012 Feb 1.
Sequestosome 1/p62 is a signal modulator or adaptor protein involved in receptor-mediated signal transduction. Sequestosome 1/p62 is gaining attention as it is involved in several diseases including Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity and insulin resistance. In this review, we will focus on the most recent advances on the physiological function of p62 relevant to human diseases.
自噬体相关蛋白 1（p62）是一种信号调节或衔接蛋白，参与受体介导的信号转导。自噬体相关蛋白 1（p62）由于与包括帕金森病、阿尔茨海默病、肝癌和乳腺癌、Pagets 骨病、肥胖和胰岛素抵抗在内的多种疾病相关，因此备受关注。在这篇综述中，我们将重点介绍与人类疾病相关的 p62 的生理功能的最新进展。
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