白鲜皮中的两种新化合物。

Two new compounds from Dictamnus dasycarpus.

作者信息

Guo Li-Na, Pei Yue-Hu, Chen Gang, Cong Huan, Liu Ji-Cheng

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

出版信息

J Asian Nat Prod Res. 2012;14(2):105-10. doi: 10.1080/10286020.2011.628316.

DOI:10.1080/10286020.2011.628316

PMID:22296149

Abstract

Two new compounds, one new pyrrolidine alkaloid and one new eudesmane-type sesquiterpene derivative, named, respectively, as dictamnaindiol and dictamnadiol, were isolated from the EtOAc soluble fraction of the ethanolic extract from the root barks of Dictamnus dasycarpus. Their structures were elucidated as (3α,4β)-3-(6-ethoxy-6-(4-hydroxyphenyl)methyl)-4-(4-hydroxyphenyl)-1-methyl-pyrrolidin-2-one (1) and (1R, 4S, 7S, 10R)-1,11-dihydroxyl-4,14-epoxy-5(6)-eudesmene (2) on the basis of their spectral and chemical analysis.

摘要

从白鲜根皮乙醇提取物的乙酸乙酯可溶部分中分离出两种新化合物，一种新的吡咯烷生物碱和一种新的桉叶烷型倍半萜衍生物，分别命名为白鲜二醇和白鲜二醛。根据光谱和化学分析，确定它们的结构分别为(3α,4β)-3-(6-乙氧基-6-(4-羟基苯基)甲基)-4-(4-羟基苯基)-1-甲基吡咯烷-2-酮(1)和(1R, 4S, 7S, 10R)-1,11-二羟基-4,14-环氧-5(6)-桉叶烯(2)。