Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
Molecules. 2018 Mar 13;23(3):642. doi: 10.3390/molecules23030642.
Eudesmane-type sesquiterpenes have been reported to exhibit varieties of biological activities. During the process of investigating this kind of natural product from the root bark of Turcz., 13 eudesmane-type sesquiterpene glycosides including six new isolates, named as dictameudesmnosides A₁ (), A₂ (), B (), C (), D (), and E (), together with seven known ones (-), were obtained. Herein, their structures were determined by the analysis of physical data, spectroscopic analysis, and chemical methods. The existence of α-configuration glucose units in their structures (-, ) is not very common in natural glycosidic components. Meanwhile, compounds -, , and - displayed TG accumulation inhibitory effects on HepG2 cells.
艾烷型倍半萜类化合物已被报道具有多种生物活性。在研究这种天然产物的过程中，我们从 Turcz. 的根皮中分离得到了 13 种艾烷型倍半萜糖苷，包括 6 种新的单体，分别命名为 dictameudesmnosides A₁ (), A₂ (), B (), C (), D (), 和 E (), 以及 7 种已知的单体 (-), 。在此，通过物理数据、光谱分析和化学方法确定了它们的结构。在其结构中，α-构型葡萄糖单元的存在（-, ）在天然糖苷成分中并不常见。同时，化合物 -,, 和 - 对 HepG2 细胞的 TG 积累具有抑制作用。
