谷胱甘肽S-转移酶M1和T1状态与喉癌风险：一项荟萃分析。
Glutathione S-transferase M1 and T1 status and the risk of laryngeal cancer: a meta-analysis.
作者信息
Kumar Vinod, Murthy A Krishna, Suresh K P
机构信息
Dept. of Oral and Maxillofacial Pathology, MS Ramaiah Dental College, Bangalore, India.
出版信息
Asian Pac J Cancer Prev. 2011;12(9):2221-6.
BACKGROUND
Polymorphic variations in GSTM1 and GSTT1 have been implicated as risk factors for various cancers. A number of studies conducted to assess their association with susceptibility to laryngeal carcinomas have yielded inconsistent and inconclusive results. In the present study, the possible association of laryngeal cancer risk with GSTM1 and GSTT1 null genotypes was explored by a meta analysis.
METHOD
A meta-analysis was carried out on case-control studies collected from the literature. The pooled odds ratio (OR) and presence of publication bias in those studies were evaluated.
RESULTS
A total of 20 studies concerning laryngeal cancer were identified. The results showed that the pooled OR was 1.22 (95% CI 1.03 1.43) for the GSTM1 polymorphism while for GSTT1 polymorphism, the pooled OR was 1.23 (95% CI 0.96-1.58). No evidence of publication bias was detected among the included studies.
CONCLUSION
The results suggest that the GSTM1 deficiency significantly increases susceptibility to laryngeal cancer whereas GSTT1 null genotype might not be a risk factor.
背景
谷胱甘肽S-转移酶M1（GSTM1）和谷胱甘肽S-转移酶T1（GSTT1）的多态性变异被认为是多种癌症的风险因素。为评估它们与喉癌易感性的关联而进行的多项研究结果并不一致且尚无定论。在本研究中，通过荟萃分析探讨了喉癌风险与GSTM1和GSTT1基因缺失型的可能关联。
方法
对从文献中收集的病例对照研究进行荟萃分析。评估这些研究中的合并比值比（OR）及发表偏倚情况。
结果
共识别出20项关于喉癌的研究。结果显示，GSTM1多态性的合并OR为1.22（95%可信区间1.03 - 1.43），而GSTT1多态性的合并OR为1.23（95%可信区间0.96 - 1.58）。纳入研究中未检测到发表偏倚的证据。
结论
结果表明，GSTM1基因缺失显著增加喉癌易感性，而GSTT1基因缺失型可能不是风险因素。
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