Xu Wei, Wang Fa, Ying Li, Wang Hong-Hui
Tumour Biol. 2014 Jan;35(1):773-7. doi: 10.1007/s13277-013-1105-4.
Glutathione S-transferase M1 (GSTM1) is one of the most important families of phase II isoenzymes known to detoxify a variety of electrophilic compounds and carcinogens. The GSTM1 null variant is associated with decreased enzyme activity, and it has been assumed to be associated with bladder cancer. The association between the GSTM1 null variant and bladder cancer in the Chinese Han population was unclear owing to the obvious inconsistency from published studies. To quantify the association between the GSTM1 null variant and bladder cancer in the Chinese Han population, we carried out the meta-analysis. We estimated the pooled odds ratio (OR) with its 95% confidence interval (95% CI) to assess the association. Eight studies with a total of 3,887 individuals were finally included into the meta-analysis. Overall, there was an obvious association between the GSTM1 null variant and risk of bladder cancer in the Chinese Han population (OR = 1.61, 95% CI 1.41–1.84, P < 0.001). There was no heterogeneity across those eight studies (I 2 = 0%). The cumulative meta-analyses showed a trend of more obvious association between the GSTM1 null variant and risk of bladder cancer in the Chinese Han population as data accumulated by year. There was no obvious evidence of publication bias in the meta-analysis. In conclusion, the GSTM1 null variant is significantly associated with risk of bladder cancer in the Chinese Han population.
谷胱甘肽S-转移酶M1（GSTM1）是已知的最重要的II期同工酶家族之一，可使多种亲电化合物和致癌物解毒。GSTM1无效变异体与酶活性降低有关，并且一直被认为与膀胱癌有关。由于已发表研究结果明显不一致，中国汉族人群中GSTM1无效变异体与膀胱癌之间的关联尚不清楚。为了量化中国汉族人群中GSTM1无效变异体与膀胱癌之间的关联，我们进行了荟萃分析。我们估计了合并比值比（OR）及其95%置信区间（95%CI）以评估这种关联。最终共有8项研究、3887名个体被纳入荟萃分析。总体而言，中国汉族人群中GSTM1无效变异体与膀胱癌风险之间存在明显关联（OR = 1.61，95%CI 1.41 - 1.84，P < 0.001）。这8项研究之间不存在异质性（I² = 0%）。累积荟萃分析表明，随着逐年积累的数据，中国汉族人群中GSTM1无效变异体与膀胱癌风险之间的关联有更明显的趋势。荟萃分析中没有明显的发表偏倚证据。总之，GSTM1无效变异体与中国汉族人群的膀胱癌风险显著相关。
