谷胱甘肽S-转移酶T1基因缺失型增加亚洲人群患结直肠癌的风险：一项荟萃分析的证据
Null genotype of GSTT1 contributes to colorectal cancer risk in Asian populations: evidence from a meta-analysis.
作者信息
Xu Donghua, Yan Shushan, Yin Jie, Zhang Pengjun
机构信息
Department of Infectious Diseases, People's Hospital of Jiangbei, Nanjing, Jiangsu, China.
出版信息
Asian Pac J Cancer Prev. 2011;12(9):2279-84.
BACKGROUND/AIMS: Studies of associations between genetic polymorphism of glutathione S-transferase T1(GSTT1) and risk of colorectal cancer (CRC) in Asian populations have reported controversial results. Thus, a meta-analysis was performed to clarify the effects of GSTT1 polymorphism on the risk of developing colorectal cancer.
METHODS
A literature search of PubMed and EMBASE up to June 7, 2011 was conducted and 13 eligible papers were finally selected, involving totals of 4,832 CRC cases and 7,045 controls. Subgroup analyses were performed according to the sample size and the research design with the software programs Review Manager (version 5.0.10) and STATA (version 9.2).
RESULTS
Analyses of all relevant studies showed an increased CRC risk was significantly associated with the null genotypes of GSTT1 (OR=1.09, 95%CI=1.01-1.17, POR=0.027; I2=40.2%). Besides, a more obvious association was observed after heterogeneity was eliminated (OR=1.13, 95%CI 1.04-1.23, POR=0.002; I2=0.0%). Subgroup analyses and sensitivity analysis further identified an association in Asians.
CONCLUSIONS
This meta-analysis demonstrated the GSTT1 null genotype to be associated with an increased risk of CRC in Asian populations.
背景/目的：关于亚洲人群中谷胱甘肽S-转移酶T1（GSTT1）基因多态性与结直肠癌（CRC）风险之间关联的研究报告了相互矛盾的结果。因此，进行了一项荟萃分析以阐明GSTT1多态性对结直肠癌发生风险的影响。
方法
检索了截至2011年6月7日的PubMed和EMBASE数据库，最终筛选出13篇符合条件的论文，共涉及4832例CRC病例和7045例对照。使用Review Manager（5.0.10版）和STATA（9.2版）软件程序，根据样本量和研究设计进行亚组分析。
结果
对所有相关研究的分析表明，CRC风险增加与GSTT1的无效基因型显著相关（OR = 1.09，95%CI = 1.01 - 1.17，P = 0.027；I² = 40.2%）。此外，消除异质性后观察到更明显的关联（OR = 1.13，95%CI 1.04 - 1.23，P = 0.002；I² = 0.0%）。亚组分析和敏感性分析进一步确定了在亚洲人群中的关联。
结论
这项荟萃分析表明，GSTT1无效基因型与亚洲人群中CRC风险增加相关。
Zotero 插件