Al-Naggar Redhwan Ahmed, Nagi Nadeem Mohammed Saeed, Ali Munef Mohammed Saleh, Almuasli Mahfoudh
Community Medicine Department, International Medical School, Management and Science University, Malaysia.
Asian Pac J Cancer Prev. 2011;12(9):2335-41.
The objective of this study is to determine the quality of life among breast cancer patients in Yemen based on socio-demographic and clinical characteristics.
This study was designed as a cross-sectional study. The data collected from 106 female breast cancer patients who were chosen for recruitment from the outpatient in National Oncology Centre (NOC), Sana'a, Yemen from November 2008 to June 2011. Questionnaires were distributed to the patients during their visit to the outpatient clinics in the center. The instrument of this study consists of two parts: Socio-demographic and the Functional Assessment of Cancer Therapy-Breast (FACT-B) questionnaire. Regarding data analysis, means and SD of subscales were evaluated for descriptive purpose. Analysis of variance (ANOVA) was performed to compare the three groups regarding QOL subscales. Whereas, independent t-test was performed for comparing two groups regarding QOL subscales. Multiple linear regression using backward analysis was performed to obtain the final model for each domain. The final model was chosen depending on R2 and the p value of the model. A p value less than 0.05 is considered statistically significant.
A total number of 106 breast cancer patients were participated in this study. The majority of them were uneducated, unemployed with normal weight and had middle income (60.4%; 95.3%; 59.4%, 46.2%; respectively). As for clinical characteristics of the study participants; the majority of them had had no family history of breast cancer, have been diagnosed at least 2 years, were diagnosed at grade 3 and size of tumor greater than 2 cm (88.7%, 66.0%, 35.8%, 73.6%; respectively). The majority of them underwent mastectomy, radiotherapy, chemotherapy and tamoxifen therapy (85.8%, 63.2%, 94.3% and 62.3%; respectively). For univariate analysis, the present study has identified several factors includes family monthly income, BMI, educational status, years after diagnosis, histological grade radiotherapy and surgery that influence the QOL of breast cancer patients in Yemen. For multivariate analysis, years after diagnosis, family monthly income and radiotherapy were significantly associated with total QOL of the breast cancer patients (p=0.01, p=0.023, p=0.039; respectively).
Family monthly income, BMI, educational status, years after diagnosis, histological grade radiotherapy and surgery were significantly influence the QOL of breast cancer patients in Yemen, in univariate analysis. For multivariate analysis, years after diagnosis, family monthly income and radiotherapy were significantly associated with total QOL of the breast cancer patients.
本研究的目的是根据社会人口统计学和临床特征来确定也门乳腺癌患者的生活质量。
本研究设计为横断面研究。数据收集自2008年11月至2011年6月在也门萨那国家肿瘤中心（NOC）门诊招募的106名女性乳腺癌患者。在患者前往该中心门诊就诊时向其发放问卷。本研究的工具包括两部分：社会人口统计学部分和癌症治疗功能评估-乳腺（FACT-B）问卷。关于数据分析，为描述目的评估各子量表的均值和标准差。进行方差分析（ANOVA）以比较三组在生活质量子量表方面的情况。而对于比较两组在生活质量子量表方面的情况则进行独立t检验。采用向后分析进行多元线性回归以获得每个领域的最终模型。根据模型的R²和p值选择最终模型。p值小于0.05被认为具有统计学意义。
共有106名乳腺癌患者参与了本研究。其中大多数人未受过教育、失业、体重正常且收入中等（分别为60.4%、95.3%、59.4%、46.2%）。至于研究参与者的临床特征；他们中的大多数人没有乳腺癌家族史，已被诊断至少2年，被诊断为3级且肿瘤大小大于2厘米（分别为88.7%、66.0%、35.8%、73.6%）。他们中的大多数人接受了乳房切除术、放疗、化疗和他莫昔芬治疗（分别为85.8%、63.2%、94.3%和62.3%）。对于单因素分析，本研究确定了几个影响也门乳腺癌患者生活质量的因素，包括家庭月收入、体重指数、教育程度、诊断后年限、组织学分级、放疗和手术。对于多因素分析，诊断后年限、家庭月收入和放疗与乳腺癌患者的总体生活质量显著相关（p值分别为0.01、0.023、0.039）。
在单因素分析中，家庭月收入、体重指数、教育程度、诊断后年限、组织学分级、放疗和手术显著影响也门乳腺癌患者的生活质量。对于多因素分析，诊断后年限、家庭月收入和放疗与乳腺癌患者的总体生活质量显著相关。
