El Haidari Rana, Abbas Linda Abou, Nerich Virginie, Anota Amélie
Environments and Health doctoral school, University of Bourgogne Franche-Comté, 25000 Besançon, France.
INSERM (French Institut of Health and Medical Research), EFS BFC (Etablissement français du sang Bourgogne franhce-comté), UMR1098 (Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique), University of Bourgogne Franche-Comté, RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France.
Cancers (Basel). 2020 Mar 16;12(3):696. doi: 10.3390/cancers12030696.
The aim of the present systematic review was to identify the factors that potentially influence health-related quality of life (HRQoL) in women with breast cancer (BC) in the Middle East.
A systematic search of the PubMed, Ovid Medline, Cochrane, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, and Ebscohost databases was conducted to identify all relevant articles published in peer-reviewed journals up to April 2018. The keywords were "Health related quality of life", "Breast Cancer", and "Middle East countries". The Newcastle-Ottawa (NOS) scale was used to evaluate the methodological quality of the included studies. Due to the methodological heterogeneity of the identified studies, no statistical pooling of the individual effect estimates was carried out; instead, the results were summarized descriptively.
A total of 5668 articles were screened and 33 studies were retained. The vast majority of these studies were cross-sectional and only two were longitudinal prospective studies. Concerning the methodological quality, only 39% were of high quality. Our comprehensive literature review identified several modifiable and non-modifiable risk factors associated with HRQoL, including sociodemographic, clinical, and treatment-related factors as well as behavioral and psychosocial factors.
This study has many implications for clinical practice and may provide a framework for establishing policy interventions to improve HRQoL among women with BC. Healthcare systems in the Middle East are encouraged to develop interventional programs targeting modifiable factors, particularly socio-demographic, behavioral, and psychosocial factors.
本系统评价的目的是确定可能影响中东地区乳腺癌（BC）女性健康相关生活质量（HRQoL）的因素。
对PubMed、Ovid Medline、Cochrane、Embase、护理及相关健康文献累积索引（CINAHL）、Scopus和Ebscohost数据库进行系统检索，以识别截至2018年4月在同行评审期刊上发表的所有相关文章。关键词为“健康相关生活质量”、“乳腺癌”和“中东国家”。采用纽卡斯尔-渥太华（NOS）量表评估纳入研究的方法学质量。由于所识别研究的方法学异质性，未对个体效应估计值进行统计合并；相反，对结果进行了描述性总结。
共筛选了5668篇文章，保留了33项研究。这些研究绝大多数为横断面研究，只有两项为纵向前瞻性研究。关于方法学质量，只有39%为高质量。我们全面的文献综述确定了几个与HRQoL相关的可改变和不可改变的风险因素，包括社会人口学、临床和治疗相关因素以及行为和心理社会因素。
本研究对临床实践有诸多启示，并可能为制定政策干预措施以改善BC女性的HRQoL提供一个框架。鼓励中东地区的医疗保健系统制定针对可改变因素的干预计划，特别是社会人口学、行为和心理社会因素。
