Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Gynecol Endocrinol. 2012 Jul;28(7):562-7. doi: 10.3109/09513590.2011.650662. Epub 2012 Feb 2.
Endometriosis is a common gynecological disease defined by extrauterine growth of endometrial glands and stroma. A variety of theories have been proposed to account for the pathogenesis of this disease, including retrograde transplantation theory, metaplasia of coelomic epithelium, hematogenic and lymphogenic spread, and remnants of the Mŭllerian duct. However, the etiopathology of endometriosis is still obscure. In this article, we aim to summarize recent researches concerning the growth mechanisms of endometriotic cells in implanted sites systematically, including the adhesion, invasion, angiogenesis, proliferation, apoptosis of endometriotic cells, variations of the immune molecules and endometriotic cells themselves, which may provide clues for future researches in the pathogenesis of endometriosis.
子宫内膜异位症是一种常见的妇科疾病，其特征是子宫内膜腺体和间质在子宫外生长。目前已经提出了多种理论来解释这种疾病的发病机制，包括逆行移植理论、体腔上皮的化生、血源性和淋巴源性播散以及米勒管残余学说。然而，子宫内膜异位症的病因仍然不清楚。在本文中，我们旨在系统地总结子宫内膜异位症细胞在植入部位生长机制的最新研究进展，包括子宫内膜异位症细胞的黏附、侵袭、血管生成、增殖、凋亡、免疫分子和子宫内膜异位症细胞自身的变化，这可能为子宫内膜异位症的发病机制的未来研究提供线索。
