Charité - Universitätsmedizin Berlin, Institut für Biochemie CVK, Oudenarder Str. 16, 13347 Berlin, Germany.
Curr Opin Immunol. 2012 Feb;24(1):77-83. doi: 10.1016/j.coi.2012.01.005. Epub 2012 Jan 31.
The immunoproteasome is a specific proteasome isoform induced by interferons. Its proteolytic function has been almost exclusively connected with the adaptive immune response and improved MHC class I antigen presentation. However, IFN-signaling also exposes cells to oxidative stress with concomitant production of nascent-oxidant damaged poly-ubiquitylated proteins. Here we discuss how immunoproteasomes protect cells against accumulation of toxic protein-aggregates and how i-proteasomes dysfunction associates with different diseases. We propose that the immunoproteasome has a central function at the interface between the innate and adaptive immune response and that its predominant protective innate function determines its favorable role in the adaptive immune response.
免疫蛋白酶体是干扰素诱导的一种特定的蛋白酶体同工型。其蛋白水解功能几乎完全与适应性免疫反应和 MHC I 类抗原提呈有关。然而，IFN 信号也会使细胞暴露于氧化应激中，同时产生新生的氧化损伤的多聚泛素化蛋白。在这里，我们讨论了免疫蛋白酶体如何保护细胞免受毒性蛋白聚集体的积累，以及 i 型蛋白酶体功能障碍如何与不同的疾病相关。我们提出，免疫蛋白酶体在先天免疫反应和适应性免疫反应之间的界面上具有核心功能，其主要的保护先天功能决定了其在适应性免疫反应中的有利作用。
