Ahmed Ali Usama, Bruno Marco J, Issa Yama, Gooszen Hein G, Fockens Paul, Boermeester Marja A
Academisch Medisch Centrum, Afd. Chirurgie, Amsterdam, the Netherlands.
Ned Tijdschr Geneeskd. 2012;156(5):A4469.
The most important symptom in patients with chronic pancreatitis is pain. This is often difficult to treat. The current treatment consists of, successively, optimal medical treatment, endoscopic intervention and finally surgical intervention. Previous research has indicated that early surgical intervention leads to better pain management and preservation of pancreatic function. Recently, the randomised multicentre 'Early surgery versus optimal current step up practice for chronic-pancreatitis' (ESCAPE) trial was started in order to evaluate whether early surgery provides better reduction of pain in comparison with present treatment. In addition, serious complications, mortality, cost-effectiveness, quality of life, pancreas insufficiency, alternative pain scores, hospital admissions and the number of interventions will be assessed.
慢性胰腺炎患者最重要的症状是疼痛。这种疼痛往往难以治疗。目前的治疗依次包括优化药物治疗、内镜干预，最后是手术干预。先前的研究表明，早期手术干预能更好地控制疼痛并保留胰腺功能。最近，一项随机多中心的“慢性胰腺炎早期手术与当前最佳逐步治疗实践对比”（ESCAPE）试验启动，旨在评估早期手术与目前治疗相比是否能更好地减轻疼痛。此外，还将评估严重并发症、死亡率、成本效益、生活质量、胰腺功能不全、替代疼痛评分、住院次数及干预次数。
