Magalhães Pedro V S, Manzolli Patricia, Walz Julio C, Kapczinski Flávio
Bipolar Disorders Program, INCT Translational Medicine & Molecular Psychiatry Laboratory, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
J Nerv Ment Dis. 2012 Feb;200(2):180-2. doi: 10.1097/NMD.0b013e3182439885.
Although depressive symptoms have been consistently associated with lower quality of life and increased disability in bipolar disorder, their relation to manic symptoms is not as clear cut. A great overlap between these outcomes complicates the understanding of how they cluster together. We used exploratory factor analysis to clarify the relation between these constructs. We consecutively recruited 320 patients with bipolar disorder, and interviewers rated the Hamilton Depression and Anxiety Rating Scales, the Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI), and the Global Assessment of Functioning (GAF). The self-rated Sheehan Disability Scale and the World Health Organization Quality of Life-BREF questionnaires were also collected. Two distinct and large dimensions emerged. Depression and anxiety, along with the self-rated scales, loaded in the first factor, whereas the YMRS, the GAF, and the CGI loaded in the second. These findings imply that evaluating self- and observer-rated outcomes may make up for a more thorough evaluation because each conveys unique illness information.
尽管抑郁症状一直与双相情感障碍患者较低的生活质量和更高的残疾程度相关，但它们与躁狂症状的关系并不那么明确。这些结果之间的大量重叠使得理解它们如何聚集在一起变得复杂。我们使用探索性因素分析来阐明这些结构之间的关系。我们连续招募了320名双相情感障碍患者，访谈者对汉密尔顿抑郁和焦虑评定量表、杨氏躁狂评定量表（YMRS）、临床总体印象（CGI）和功能总体评定量表（GAF）进行了评分。还收集了自评的希恩残疾量表和世界卫生组织生活质量简表问卷。出现了两个不同的大维度。抑郁和焦虑，以及自评量表，加载在第一个因素中，而YMRS、GAF和CGI加载在第二个因素中。这些发现意味着评估自评和观察者评定的结果可能有助于更全面的评估，因为每个结果都传达了独特的疾病信息。
