Gazalle Fernando Kratz, Hallal Pedro Curi, Andreazza Ana Cristina, Frey Benício Noronha, Kauer-Sant'Anna Márcia, Weyne Fernanda, da Costa Sabrina Corrêa, Santin Aida, Kapczinski Flávio
Psychiatric Research Unit, Post-Graduate Psychiatry Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Psychiatry Res. 2007 Sep 30;153(1):33-8. doi: 10.1016/j.psychres.2006.07.007. Epub 2007 Jun 4.
This study evaluates the influence of manic symptoms on quality of life in a sample of adult bipolar disorder (BD) patients. This was a cross-sectional study including 125 BD outpatients from a university-based program. All patients were diagnosed using the Structured Clinical Interview for DSM-IV for BD. Manic symptoms and quality of life were assessed using the Young Mania Rating Scale (YMRS) and the World Health Organization Quality of Life Instrument-Short Version (WHOQOL-BREF), respectively. In the unadjusted analysis using linear regression, the score of manic symptoms was inversely associated with scores of quality of life within the social domain of the WHOQOL. In the adjusted analysis, the score of manic symptoms was inversely associated with the social, physical, and psychological domains of the WHOQOL. In a separate analysis at the YMRS items, items 4 (irritability) and 5 (sleep) were associated with lower quality of life.
本研究评估了成年双相情感障碍（BD）患者样本中躁狂症状对生活质量的影响。这是一项横断面研究，纳入了来自一个大学项目的125名BD门诊患者。所有患者均使用《精神疾病诊断与统计手册第四版》（DSM-IV）双相情感障碍的结构化临床访谈进行诊断。分别使用杨氏躁狂评定量表（YMRS）和世界卫生组织生活质量量表简表（WHOQOL-BREF）评估躁狂症状和生活质量。在使用线性回归的未调整分析中，躁狂症状评分与WHOQOL社会领域的生活质量评分呈负相关。在调整分析中，躁狂症状评分与WHOQOL的社会、身体和心理领域呈负相关。在YMRS项目的单独分析中，项目4（易激惹）和项目5（睡眠）与较低的生活质量相关。
