CHU Timone, Service de Neurophysiologie Clinique,Marseille, France.
J Neurol Neurosurg Psychiatry. 2012 May;83(5):522-8. doi: 10.1136/jnnp-2011-301219. Epub 2012 Jan 31.
Recent investigations have suggested that the occurrence of epileptic seizures is not completely random. In particular, various types of psychological changes or life events may act as triggering factors.
To identify a possible link between self-perception of the impact of affective precipitants, cognitive responses modulated by aversive information and brain metabolic modifications in patients with temporal lobe epilepsy (TLE).
The extent to which seizures were elicited or not by emotional precipitants was estimated using a self-reported scale, allowing distinction of two groups: 'Emo-TLE' group (patients reporting to have seizures triggered by emotional events) and 'Other-TLE' group, which were compared with healthy individuals ('control' group). Attentional biases were investigated using the probe detection paradigm, using negative and neutral stimuli. Interictal brain metabolism was studied using FDG-PET, and comparison was made between controls, Emo-TLE and Other-TLE groups.
Patients with emotional vulnerability (Emo-TLE) disclosed specific attentional biases towards negative stimuli compared with the Other-TLE and control groups. Patients with Emo-TLE also exhibited specific hypometabolism in the anterior temporal lobe, including amygdala and hippocampus. The degree of attentional biases correlated with decreased metabolism in these regions.
This investigation shows that the impact of affective events is the result of self-perception and also that it might be determined by specific cognitive and brain metabolic modifications in TLE.
最近的研究表明，癫痫发作的发生并非完全随机。特别是，各种类型的心理变化或生活事件可能充当触发因素。
确定情感诱发物的自我感知、厌恶信息调节的认知反应与颞叶癫痫（TLE）患者大脑代谢改变之间可能存在的联系。
使用自我报告量表来估计情绪诱发物是否引发癫痫发作，从而区分两个组：“情绪 TLE”组（报告情绪事件引发癫痫发作的患者）和“其他 TLE”组，并与健康个体（“对照组”）进行比较。使用负性和中性刺激使用探针检测范式研究注意偏向。使用 FDG-PET 研究间发性脑代谢，并对对照组、情绪 TLE 组和其他 TLE 组进行比较。
情绪脆弱的患者（情绪 TLE 组）与其他 TLE 组和对照组相比，对负性刺激表现出特定的注意偏向。情绪 TLE 患者在前颞叶区域，包括杏仁核和海马体，也表现出特定的代谢低下。这些区域的代谢减少与注意力偏向的程度相关。
这项研究表明，情感事件的影响是自我感知的结果，并且可能由 TLE 中的特定认知和大脑代谢改变决定。
