Preglej Lidija, Marinkovic Ksenija, Hećimović Hrvoje
Language and Cognitive Neuroscience, Interdisciplinary Scientific Postgraduate Program, University of Zagreb, 10000 Zagreb, Croatia.
Department of Psychology, San Diego State University, San Diego, CA 92182, USA.
Brain Sci. 2021 Oct 24;11(11):1402. doi: 10.3390/brainsci11111402.
We examined whether word processing is associated with subjective self-evaluation of cognition in patients with mesial temporal lobe epilepsy (MTLE) as a function of their depressive symptoms. MTLE patients with (MTLE +d, = 28) or without (MTLE -d, = 11) depression were compared to pair-matched healthy control participants on free recall and self-relevance ratings of emotionally valenced words. Correlation and hierarchical analyses were conducted to investigate whether the subjective self-evaluation of cognition in MTLE patients is predicted by the negative emotional bias reflected in task performance. MTLE +d patients endorsed as self-relevant fewer positive words and more negative words than the MTLE -d patients and healthy participants. They also self-evaluated their cognition poorer than the MTLE -d patients. Analyses indicated that recall and self-endorsement of emotional words predicted both self-evaluation of cognition as well as epilepsy duration. Our findings indicate that negative self-relevance emotional bias is observed in MTLE patients and is predictive of subjective self-evaluation of cognition. Application of brief behavioral tasks probing emotional functions could be valuable for clinical research and practice in the patients with MTLE.
我们研究了文字处理是否与内侧颞叶癫痫（MTLE）患者的认知主观自我评价相关，该评价作为其抑郁症状的函数。将患有抑郁症的MTLE患者（MTLE +d，n = 28）或未患抑郁症的MTLE患者（MTLE -d，n = 11）与配对的健康对照参与者进行比较，以评估情绪效价词的自由回忆和自我相关性评分。进行了相关性和层次分析，以研究MTLE患者认知的主观自我评价是否由任务表现中反映的负性情绪偏差所预测。与MTLE -d患者和健康参与者相比，MTLE +d患者认可为与自我相关的积极词汇更少，消极词汇更多。他们对自己认知的自我评价也比MTLE -d患者差。分析表明，情绪词汇的回忆和自我认可既预测了认知的自我评价，也预测了癫痫持续时间。我们的研究结果表明，在MTLE患者中观察到负性自我相关性情绪偏差，并且该偏差可预测认知的主观自我评价。应用简短的行为任务来探究情绪功能，对于MTLE患者的临床研究和实践可能具有重要价值。
