降钙素基因相关肽和血管活性肠肽对人体尼古丁诱导出汗的影响。

Effects of calcitonin gene-related peptide and vasoactive intestinal peptide on nicotine-induced sweating in man.

作者信息

Tanaka E, Uchiyama S, Nakano S

机构信息

Department of Physiology, Tokai University School of Medicine, Isehara, Japan.

出版信息

J Auton Nerv Syst. 1990 Jul;30(3):265-8. doi: 10.1016/0165-1838(90)90258-k.

DOI:10.1016/0165-1838(90)90258-k

PMID:2229893

Abstract

The effects of two neuropeptides, calcitonin gene-related peptide and vasoactive intestinal peptide on nicotine-induced sweating in human skin were investigated. Intradermal injection of nicotine induced local sweating and each peptide, administered together with nicotine, inhibited these responses in a concentration-dependent manner. The concentration of calcitonin gene-related peptide for threshold and half-maximum inhibition were about 10(-10) M and 10(-8) M, respectively, while those of vasoactive intestinal peptide were approximately 10(-9) M and 10(-7) M, respectively. The results suggest that calcitonin gene-related peptide and vasoactive intestinal peptide have inhibitory effects on the nicotinic action, and release of endogenous calcitonin gene-related peptide and/or vasoactive intestinal peptide may influence sweating in human skin under physiological conditions in vivo.

摘要

研究了两种神经肽，降钙素基因相关肽和血管活性肠肽对人体皮肤尼古丁诱导出汗的影响。皮内注射尼古丁可诱导局部出汗，与尼古丁一起给药的每种肽均以浓度依赖性方式抑制这些反应。降钙素基因相关肽的阈值浓度和半数最大抑制浓度分别约为10^(-10) M和10^(-8) M，而血管活性肠肽的阈值浓度和半数最大抑制浓度分别约为10^(-9) M和10^(-7) M。结果表明，降钙素基因相关肽和血管活性肠肽对烟碱作用具有抑制作用，内源性降钙素基因相关肽和/或血管活性肠肽的释放可能在体内生理条件下影响人体皮肤出汗。