Zijlstra Freek J, van den Berg-de Lange Ineke, Huygen Frank J P M, Klein Jan
Department of Anesthesiology, Erasmus Medical Centre, Centre location, Rotterdam, The Netherlands.
Mediators Inflamm. 2003 Apr;12(2):59-69. doi: 10.1080/0962935031000114943.
Acupuncture has a beneficial effect when treating many diseases and painful conditions, and therefore is thought to be useful as a complementary therapy or to replace generally accepted pharmacological intervention. The attributive effect of acupuncture has been investigated in inflammatory diseases, including asthma, rhinitis, inflammatory bowel disease, rheumatoid arthritis, epicondylitis, complex regional pain syndrome type 1 and vasculitis. Large randomised trials demonstrating the immediate and sustained effect of acupuncture are missing. Mechanisms underlying the ascribed immunosuppressive actions of acupuncture are reviewed in this communication. The acupuncture-controlled release of neuropeptides from nerve endings and subsequent vasodilative and anti-inflammatory effects through calcitonine gene-related peptide is hypothesised. The complex interactions with substance P, the analgesic contribution of beta-endorphin and the balance between cell-specific pro-inflammatory and anti-inflammatory cytokines tumour necrosis factor-alpha and interleukin-10 are discussed.
针刺疗法在治疗多种疾病和疼痛状况时具有有益效果，因此被认为作为一种辅助疗法或替代普遍接受的药物干预手段是有用的。针刺疗法的归因效应已在包括哮喘、鼻炎、炎症性肠病、类风湿性关节炎、网球肘、1型复杂性区域疼痛综合征和血管炎在内的炎症性疾病中进行了研究。目前尚缺乏证明针刺疗法即时和持续效果的大型随机试验。本文对针刺疗法所谓免疫抑制作用的潜在机制进行了综述。有人提出针刺疗法可控制神经末梢释放神经肽，并通过降钙素基因相关肽产生随后的血管舒张和抗炎作用。文中还讨论了与P物质的复杂相互作用、β-内啡肽的镇痛作用以及细胞特异性促炎细胞因子和抗炎细胞因子肿瘤坏死因子-α与白细胞介素-10之间的平衡。
