Department of Urology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
BJU Int. 2010 Apr;105(8):1046-58. doi: 10.1111/j.1464-410x.2010.09317.x.
Botulinum toxins (BoNTs) are known for their ability to potently and selectively modulate neurotransmission for successful long-term treatment of muscle hypercontractility. Recent studies suggest that BoNT has effects on modulation of sensory processing, inflammation and glandular function. Urologists and urogynaecologists have become interested in the potential application of BoNTs in patients with lower urinary tract symptoms, including detrusor and sphincter overactivity, bladder hypersensitivity, interstitial cystitis/painful bladder symptoms and benign prostatic hyperplasia. We review the biological action of BoNT in bladder and prostate, and present the techniques and results of the clinical studies with BoNT in the lower urinary tract.
肉毒毒素（BoNTs）以其强大而选择性地调节神经传递的能力而闻名，可成功长期治疗肌肉过度收缩。最近的研究表明，BoNT 对感觉处理、炎症和腺体功能的调节具有影响。泌尿科医生和妇科泌尿科医生对 BoNT 在以下尿路症状患者中的潜在应用产生了兴趣，包括逼尿肌和括约肌过度活动、膀胱过度敏感、间质性膀胱炎/膀胱疼痛症状和良性前列腺增生。我们回顾了 BoNT 在膀胱和前列腺中的生物学作用，并介绍了 BoNT 在下尿路中的临床研究技术和结果。
