Institute of Molecular Medicine, Peking University, Beijing, China.
Curr Mol Med. 2012 Mar;12(3):247-58. doi: 10.2174/156652412799218886.
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that have critical regulatory functions in various biological processes. MicroRNA-22 (miR-22) is a highly-conserved 22-nt miRNA, whose roles in human diseases and normal physiology are just beginning to emerge. Recently, miR-22 has been connected to a great number of activities that encompass tumorigenesis, epigenetic modification, embryonic development, skeletal metabolism, panic disorder, and cardiomyocyte hypertrophy. Aberrant expression of miR-22 has been identified in multiple human diseases. Here, we describe our current understanding of the roles of miR-22 and its signaling circuitry in pathology and physiology, and discuss important advances that set the scene for applying miR-22 to the prevention and treatment of a wide range of human diseases.
微小 RNA（miRNAs）是一类丰富的小非编码 RNA，在各种生物学过程中具有关键的调节功能。微小 RNA-22（miR-22）是一种高度保守的 22nt miRNA，其在人类疾病和正常生理中的作用才刚刚开始显现。最近，miR-22 与许多活动有关，包括肿瘤发生、表观遗传修饰、胚胎发育、骨骼代谢、惊恐障碍和心肌细胞肥大。miR-22 的异常表达已在多种人类疾病中得到鉴定。在这里，我们描述了我们目前对 miR-22 及其信号通路在病理学和生理学中的作用的理解，并讨论了为将 miR-22 应用于预防和治疗广泛的人类疾病奠定基础的重要进展。
