Ip Y K, Khan M M
Department of Zoology, National University of Singapore, Kent Ridge.
J Helminthol. 1990 Sep;64(3):203-11. doi: 10.1017/s0022149x00012177.
5-Hydroxytryptamine (5-HT) (1,2 and 5 mM) significantly stimulated the incorporation of radioactive inorganic phosphate (32Pi) into phosphatidylinositol, phosphatidylethanolamine, phosphatidic acid and also total phospholipid fraction of Hymenolepis diminuta after one hour of incubation. Such effect was both time and concentration dependent. In the presence of 5-HT early labelling of phosphatidylinositol was observed. Also, the percentage stimulation by 5-HT was the highest in this fraction under all experimental conditions. The inorganic, organic, total and phosphatidylcholine-bound phosphate of H. diminuta incubated with 5-HT were not significantly different from those of the control under all incubation conditions. Results reported herein suggest that messenger molecules that are derived from phosphoinositides may be involved in the stimulatory mechanism of 5-HT in H. diminuta.
5-羟色胺（5-HT）（1、2和5毫摩尔）在孵育1小时后，显著刺激微小膜壳绦虫将放射性无机磷酸盐（32Pi）掺入磷脂酰肌醇、磷脂酰乙醇胺、磷脂酸以及总磷脂部分。这种作用具有时间和浓度依赖性。在5-HT存在的情况下，观察到磷脂酰肌醇的早期标记。此外，在所有实验条件下，5-HT对该部分的刺激百分比最高。在所有孵育条件下，与5-HT一起孵育的微小膜壳绦虫的无机磷、有机磷、总磷以及与磷脂酰胆碱结合的磷与对照组相比均无显著差异。本文报道的结果表明，源自磷酸肌醇的信使分子可能参与了5-HT对微小膜壳绦虫的刺激机制。
