Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan.
Kaohsiung J Med Sci. 2012 Feb;28(2 Suppl):S26-32. doi: 10.1016/j.kjms.2011.08.005. Epub 2012 Jan 9.
Physical aspects of medical science involve making physical models, physical approaches, and measurements by physical instruments. Among these, the physical approach is the most important for an exact elucidation of the physiological function of living materials. What is a physical approach? In the first step, the molecular mechanism of visual transduction will be demonstrated by considering the physical characteristics of diffusion of second messengers. In the next step, I will consider how frequency modulation-type impulse signaling is converted from amplitude modulation-type electric signaling. In the last section, I will discuss how impulse signaling (i.e., the train of action potentials) is processed by the neural network in the brain and eventually is recognized in the frontal cortex using near infrared spectroscopy. In order to obtain such a physical model of vision, many physical concepts are used, such as light reflex, energy transduction, diffusion of molecules, threshold, the Coulomb interaction, light absorption, and cluster analysis. Among them, the Coulomb interaction, light absorption, and diffusion of molecules are three essential keywords for the physical process.
医学科学的物理方面涉及制作物理模型、采用物理方法和使用物理仪器进行测量。在这些方面中,物理方法对于准确阐明生命物质的生理功能最为重要。什么是物理方法呢?在第一步中,将考虑第二信使扩散的物理特性,从而展示视觉转导的分子机制。在下一步中,我将考虑频率调制型脉冲信号如何从幅度调制型电信号转换。在最后一节中,我将讨论脉冲信号(即一连串动作电位)如何在大脑中的神经网络中进行处理,最终使用近红外光谱在额皮质中被识别。为了获得这样的视觉物理模型,使用了许多物理概念,例如光反射、能量转换、分子扩散、阈值、库仑相互作用、光吸收和聚类分析。其中,库仑相互作用、光吸收和分子扩散是物理过程的三个关键术语。