Carrasco-Valiente J, Anglada-Curado F J, Aguilar-Melero P, González-Ojeda R, Muntané-Relat J, Padillo-Ruiz F J, Requena-Tapia M J
Unidad de Gestión Clínica de Urología, Hospital Universitario Reina Sofía, Córdoba, España.
Actas Urol Esp. 2012 May;36(5):296-301. doi: 10.1016/j.acuro.2011.08.004. Epub 2012 Feb 1.
This present study has aimed to assess the state of acute phase markers and oxidative stress in patients with kidney stones.
A prospective study was carried out on 100 patients with kidney stones and 25 healthy controls. Albumin, ß2 microglobulin, Gamma-glutamyl transpepsidase, Lactate dehydrogenase, Tumor necrosis factor alpha, Interleukin 1 and Interleukin-6 were evaluated as acute phase markers and lipid peroxidation products, Superoxide dismutase and Glutathione peroxidase levels acted as oxidative stress markers.
An increase in renal cell damage markers as expressed by the ß2 microglobulin (p=0.04), albumin (p=0.004), Lactate dehydrogenase (p=0.001) and Gamma glutamyl transpepsidasa (p=0.01) was observed in the patient group. There was a direct correlation between levels of ß2 microglobulin and stone size (r=0.3, p=0.03). The association between stone size and cytokine activation was observed to be stronger in patients with staghorn calculi. In these patients, Tumor necrosis factor alpha (p=0.011), Interleukin 1 (p=0.004) and Interleukin 6 (p=0.004) were significantly higher. Patients with stones in the urinary tract showed data of significantly higher oxidative stress, expressed as an increase in levels of lipid peroxidation products (p=0.03) and a decrease in the antioxidant activity of Superoxide dismutase (p=0.03) and Glutathione peroxidase (p=0.002).
Patients undergoing urolithiasis showed an elevation of acute phase markers, associated with oxidative stress as expressed by an increase in lipid peroxidation products and a decrease in the antioxidant enzyme activity.
本研究旨在评估肾结石患者的急性期标志物和氧化应激状态。
对100例肾结石患者和25例健康对照者进行了一项前瞻性研究。评估了白蛋白、β2微球蛋白、γ-谷氨酰转肽酶、乳酸脱氢酶、肿瘤坏死因子α、白细胞介素1和白细胞介素-6作为急性期标志物，脂质过氧化产物、超氧化物歧化酶和谷胱甘肽过氧化物酶水平作为氧化应激标志物。
在患者组中观察到β2微球蛋白（p = 0.04）、白蛋白（p = 0.004）、乳酸脱氢酶（p = 0.001）和γ-谷氨酰转肽酶（p = 0.01）所表达的肾细胞损伤标志物增加。β2微球蛋白水平与结石大小之间存在直接相关性（r = 0.3，p = 0.03）。在鹿角形结石患者中，观察到结石大小与细胞因子激活之间的关联更强。在这些患者中，肿瘤坏死因子α（p = 0.011）、白细胞介素1（p = 0.004）和白细胞介素6（p = 0.004）显著更高。尿路结石患者表现出氧化应激显著更高的数据，表现为脂质过氧化产物水平增加（p = 0.03）以及超氧化物歧化酶（p = 0.03）和谷胱甘肽过氧化物酶（p = 0.002）的抗氧化活性降低。
患有尿石症的患者表现出急性期标志物升高，与脂质过氧化产物增加和抗氧化酶活性降低所表达的氧化应激相关。
