Germi L, De Giorgi V, Bergamo F, Niccoli M C, Kokelj F, Simonacci M, Satriano R A, Priano L, Massone C, Pigatto P, Filosa G, De Bitonto A, Fornasa C Veller
Dermatology Unit, San Bortolo Hospital, Vicenza, Italy.
Dermatol Online J. 2012 Jan 15;18(1):11.
This is a multicentric, observational and controlled study designed to verify the existence of a significant association between plaque-type psoriasis and oral lesions, such as geographic tongue and/or fissured tongue.
during a period of 9 months all consecutive patients with plaque-type psoriasis were enrolled using simple nonrandom (sequential) sampling. The control group included healthy subjects presenting to the same Dermatology centers to monitor pigmented skin lesions; the patients were matched for age and sex. All patients were examined for oral lesions.
Out of a total of 535 psoriatic patients and 436 control group patients, oral mucosal lesions were detected in 188 (35.1%) and 86 (19.7%) cases, respectively, and the difference is statistically significant. Fissured tongue (FT) and geographic tongue (GT), which were most frequently detected, were seen more frequently in psoriatic patients (FT: 22.6%; GT: 9.1%) than the control group (FT: 10.3%; GT: 5.2%) (p<0.05).
On the basis of the similar studies reported in the literature and the large number of patients involved in our study, we can conclude that FT and GT can be clearly suggested as oral manifestations of plaque-type psoriasis, although the reason for this association is not clear.
这是一项多中心、观察性和对照性研究，旨在验证斑块型银屑病与口腔病变（如地图舌和/或沟纹舌）之间是否存在显著关联。
在9个月的时间里，采用简单非随机（序贯）抽样方法纳入所有连续性斑块型银屑病患者。对照组包括到同一皮肤科中心监测色素沉着性皮肤病变的健康受试者；患者按年龄和性别进行匹配。所有患者均接受口腔病变检查。
在总共535例银屑病患者和436例对照组患者中，分别有188例（35.1%）和86例（19.7%）检测到口腔黏膜病变，差异具有统计学意义。最常检测到的沟纹舌（FT）和地图舌（GT）在银屑病患者中的出现频率（FT：22.6%；GT：9.1%）高于对照组（FT：10.3%；GT：5.2%）（p<0.05）。
根据文献报道的类似研究以及我们研究中涉及的大量患者，我们可以得出结论，尽管这种关联的原因尚不清楚，但FT和GT可明确被认为是斑块型银屑病的口腔表现。
